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Cialis (tadalafil)

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Quick Overview

Cialis Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Uae has no effect in the absence of sexual arousal.


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Information

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Comprar Cialis Online Mexico compared to placebo.

The efficacy and safety of Cialis Online Miglior Prezzo (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Uae 1 time per day. In studies of the primary efficacy of Cialis Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis 20 Mg Price Uae in patients with BPH — inhibition of PDE-5 Cialis Uae, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Farmacia Online España Cialis Uae according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Buy Cialis Over The Counter Usa at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Uae. The maximum daily dose of Cialis Online Italia Consegna Veloce is 20 mg.

The use of Comprar Cialis Online En Usa Cialis Uae for indication of BPH or ED/BPH.The recommended dose of Cialis Uae when used once a day is 5 mg; Cialis Online Miglior Prezzo should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Can I Buy Cialis Over The Counter Australia once a day is not recommended.

Effect of Cialis Uae on other drugs

It is known that Cialis Uae increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Uae in patients receiving nitrates is contraindicated.

Cialis Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Uae does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Uae does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Uae does not affect the action of warfarin against PV.

Cialis Uae does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Uae has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis Uae should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Uae in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Uae with doxazosin is contraindicated. When using Cialis Uae healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Buy Cialis Taiwan did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Uae. At high doses of alcohol (0.7 g/kg), Cialis Uae did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Comprar Cialis Online En Usa in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis Uae has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Peculiar properties

On sale Cialis Uae first appeared in 2003 and immediately attracted the attention of the target audience: at that time, many wanted to buy not viagra and Cialis Uae. As a result, the sale soon appeared exact copies of Cialis Uae — generics, which accurately repeated the composition of the original substance, but cost much less.

Whether it is possible to buy generic Cialis Uae, whether it will harm health — similar thoughts arise in many who want to buy Cialis Online Miglior Prezzo. I must say that such doubts are in vain, as Cialis Uae-copy passes the same tests and tests as the original. In addition, the branded drug is quite expensive, and not everyone can buy it.

The effect on the body Cialis Uae is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Cialis Uae is based on the properties of Cialis Uae, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

The long-term effect of Cialis Uae allows you not to worry about what you need to do everything in time: taking a pill, a man will be able to quality sexual intercourse within 1.5 days.

What else is the argument for purchasing Cialis Buy South Africa?

Many men want to buy generic Cialis Uae, not viagra, as in parallel with taking the pill you can drink alcohol and eat (even fat) without any health consequences. In addition, Cialis Uae does not serve as a reason for excitement, but only normalizes erectile function, allowing men to lead a full sexual life.

In addition, clinical trials have shown that men who underwent therapeutic treatment with Cialis Uae, noticed an improvement in erection and after taking generic.

Effect of other drugs on Cialis Uae

Cialis Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Online Kopen Ervaringen in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Uae Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Uae in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Uae activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Uae (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Uae Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Comprare Cialis Online è Legale in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Uae reduces the rate of absorption of Cialis Uae without changing the area under the pharmacokinetic curve for Cialis Online Kaufen Ohne Rezept. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Uae.

The safety and effectiveness of the combination of Cialis Uae with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis Uae does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

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