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Information

Pharmacokinetics

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The pharmacokinetics of Buy Cialis Johannesburg in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Buy Cialis Johannesburg 1 time/day.

The average Vd is about 63 liters, which indicates that Buy Cialis Johannesburg is distributed in the tissues of the body.

The plasma protein binding of Buy Cialis Johannesburg at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Buy Cialis Johannesburg is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Buy South Africa. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Online Kaufen Ohne Rezept when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Buy Cialis Johannesburg is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Buy Cialis Johannesburg when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

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The pharmacokinetics of Cialis Online Italia Consegna Veloce in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Online San Marino Buy Cialis Johannesburg® patients with severe liver failure must first assess the risk and benefit of Cialis Online Miglior Prezzo.

In patients with diabetes mellitus during the use of Cialis Farmacia Online España AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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Buy Cialis Johannesburg is a drug that has long gained popularity in men who have a weak or unstable erection. A huge number of clinical studies and experiments were conducted, in which several thousand people with erectile dysfunction participated. The effectiveness of Buy Cialis Johannesburg was 81%, this percentage of men was able to fully restore the "normal" erection, the rest got rid of their ailments, depending on the degree of complexity of the disease. Agree, this is an amazing result!

The main feature of Buy Cialis Johannesburg is the ability to restore an erection for 36 hours after taking the pill, which will occur only with sexual arousal. That allows partners not to adapt to a certain time of Buy Cialis Johannesburg, and lead a normal life before the natural desire. In addition, the effectiveness of Buy Cialis Johannesburg will not affect a hearty dinner or drunk alcohol, which is also a definite plus for men of any age.

Action of preparation

We all understand that the main effect of the action of Buy Cialis Johannesburg should be only one – increasing potency in men. This is exactly what happens after the use of Buy Cialis Johannesburg, with sexual arousal: the blood vessels of the penis expand, after which it receives a more enhanced blood flow, thereby creating a "normal" erection. A noticeable improvement in potency can be observed within 20 minutes after the use of Buy Cialis Johannesburg.

Application and dosage

Tablets are used inside and washed down with water, regardless of the meal. The minimum time before presumable sexual intercourse has to make 20 minutes. Most often, doctors recommend a dose of 20 mg. After that, for 36 hours, you can at any moment be in full sexual readiness. The maximum frequency of admission should not exceed 1 time per day. For the elderly, no changes in the dosage and application does not exist.

Mechanism of action

The active substance of Buy Cialis Johannesburg is Cialis 5 Mg Online Italia, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Buy Cialis Johannesburg.

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The duration of the generic Buy Cialis Johannesburg reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Buy Cialis Johannesburg should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Clinical pharmacology

Several studies have been conducted to assess the effect of daily Buy Cialis Johannesburg on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Cialis Johannesburg compared to placebo.

The efficacy and safety of Buy Cialis Johannesburg (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Buy Cialis Johannesburg 1 time per day. In studies of the primary efficacy of Buy Cialis Johannesburg at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Buy Cialis Johannesburg at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Buy Cialis Johannesburg in patients with BPH — inhibition of PDE-5 Buy Cialis Johannesburg, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Online Bestellen Erfahrungen Buy Cialis Johannesburg according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Buy Cialis Johannesburg at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Johannesburg. The maximum daily dose of Cialis 5mg Daily Buy Online is 20 mg.

The use of Buy Cialis Johannesburg Buy Liquid Cialis for indication of BPH or ED/BPH.The recommended dose of Buy Cialis Johannesburg when used once a day is 5 mg; Buy Cialis Over The Counter In Canada should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Comprar Cialis Online En Usa once a day is not recommended.

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