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Information

Clinical pharmacology

Cialis Tablets In Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Tablets In Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Tablets In Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Tablets In Uae is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Online Kopen Nederland on PDE-5 is more active than on other PDES. Buy Cialis Medication is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Tablets In Uae is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis Tablets In Uae is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Tablets In Uae is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Tablets In Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis Tablets In Uae in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Tablets In Uae does not cause a significant change in heart rate.

Cialis Tablets In Uae does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Tablets In Uae on visual acuity, electroretinogram, intraocular pressure and pupil size.

Effect of other drugs on Cialis Tablets In Uae

Viagra Cialis Vendita Online is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Buy Cialis Taiwan in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Tablets In Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Tablets In Uae Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Online Kaufen Ohne Rezept in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Tablets In Uae activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Malaysia Where To Buy (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis 5mg Price In Uae Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Tablets In Uae in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Tablets In Uae reduces the rate of absorption of Cialis Tablets In Uae without changing the area under the pharmacokinetic curve for Cialis Tablets In Uae. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Tablets In Uae.

The safety and effectiveness of the combination of Comprar Cialis Online En Usa with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis Tablets In Uae does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Where Can You Buy Cialis Over The Counter on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Cialis Super Active compared to placebo.

The efficacy and safety of Cialis Tablets In Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Tablets In Uae 1 time per day. In studies of the primary efficacy of Cialis Tablets In Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Generico Online Recensioni at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Tablets In Uae in patients with BPH — inhibition of PDE-5 Cialis Tablets In Uae, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Tablets In Uae Cialis Buy Malaysia according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Online Kaufen Schweiz at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Tablets In Uae. The maximum daily dose of Cialis Tablets In Uae is 20 mg.

The use of Cialis Tablets In Uae Cialis Generico Online Mexico for indication of BPH or ED/BPH.The recommended dose of Cialis Tablets In Uae when used once a day is 5 mg; Cialis Kupovina Online should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Tablets In Uae once a day is not recommended.

Effect of Cialis Tablets In Uae on other drugs

It is known that Cialis Tablets In Uae increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tablets In Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Tablets In Uae in patients receiving nitrates is contraindicated.

Cialis Tablets In Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Tablets In Uae does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Where Can I Buy Cialis Over The Counter Usa does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Tablets In Uae does not affect the action of warfarin against PV.

Cialis Tablets In Uae does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Tablets In Uae has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Buy Cialis Over The Counter Canada should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Tablets In Uae in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Tablets In Uae with doxazosin is contraindicated. When using Cialis Tablets In Uae healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Buy Cialis Discount did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Tablets In Uae. At high doses of alcohol (0.7 g/kg), Cialis Tablets In Uae did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis Tablets In Uae in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

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