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The pharmacokinetics of Cialis 20mg Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis 20mg Uae Cialis 20mg Uae® patients with severe liver failure must first assess the risk and benefit of Cialis 20mg Uae.


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Information

Mechanism of action

The active substance of Cialis Buy South Africa is Cialis Online Miglior Prezzo, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis 20mg Uae.

Rules of admission

The duration of the generic Cialis 20mg Uae reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis 20mg Uae should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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About Cialis 20mg Uae

Cialis 20mg Uae is a drug that has long gained popularity in men who have a weak or unstable erection. A huge number of clinical studies and experiments were conducted, in which several thousand people with erectile dysfunction participated. The effectiveness of Cialis 20mg Uae was 81%, this percentage of men was able to fully restore the "normal" erection, the rest got rid of their ailments, depending on the degree of complexity of the disease. Agree, this is an amazing result!

The main feature of Cialis 20mg Uae is the ability to restore an erection for 36 hours after taking the pill, which will occur only with sexual arousal. That allows partners not to adapt to a certain time of Cialis 20mg Uae, and lead a normal life before the natural desire. In addition, the effectiveness of Cialis 20mg Uae will not affect a hearty dinner or drunk alcohol, which is also a definite plus for men of any age.

Action of preparation

We all understand that the main effect of the action of Buy Liquid Cialis should be only one – increasing potency in men. This is exactly what happens after the use of Cialis 20mg Uae, with sexual arousal: the blood vessels of the penis expand, after which it receives a more enhanced blood flow, thereby creating a "normal" erection. A noticeable improvement in potency can be observed within 20 minutes after the use of Cialis Veilig Online Kopen.

Application and dosage

Tablets are used inside and washed down with water, regardless of the meal. The minimum time before presumable sexual intercourse has to make 20 minutes. Most often, doctors recommend a dose of 20 mg. After that, for 36 hours, you can at any moment be in full sexual readiness. The maximum frequency of admission should not exceed 1 time per day. For the elderly, no changes in the dosage and application does not exist.

Clinical pharmacology

Cialis 20mg Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis 20mg Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis 20mg Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis 20mg Uae is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Buy Liquid Cialis on PDE-5 is more active than on other PDES. Cialis 20mg Uae is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis 20mg Uae is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis 20mg Uae is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Buy Cialis Denmark is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Generico Online España improves erection and increases the possibility of a full sexual intercourse.

Cialis 20mg Uae in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis 20mg Uae does not cause a significant change in heart rate.

Cialis 20mg Uae does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Buy Cialis Miami on visual acuity, electroretinogram, intraocular pressure and pupil size.

Dosage and administration

Inside. Use of Cialis Online Kaufen Forum Cialis 20mg Price In Uae according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Generico Online Mexico at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis 20mg Uae. The maximum daily dose of Cialis 20mg Uae is 20 mg. the Use of Cialis 20mg Uae according to the indication of BPH or ED/BPH. The recommended dose of Cialis Legal Online Bestellen when used once a day is 5 mg; Cialis 20mg Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis 20mg Uae is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Can I Buy Cialis Over The Counter Canada at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis 20mg Uae in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis 20mg Uae practically displayed.

Interaction with other drugs

Cialis 20mg Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis 20mg Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis 20mg Uae reduced the rate of absorption of the latter without changing the AUC. Buy Cialis Over The Counter enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Buy Cialis Jakarta on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated

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