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Information

Clinical pharmacology

Cialis In Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis 5mg Price In Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis In Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis In Uae is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis In Uae on PDE-5 is more active than on other PDES. Cialis In Uae is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis In Uae is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Buy Cialis Super Active is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis In Uae is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis In Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis Online Snabb Leverans in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis In Uae does not cause a significant change in heart rate.

Cialis Farmacia Online España does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Online Bestellen Erfahrungsberichte on visual acuity, electroretinogram, intraocular pressure and pupil size.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis In Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis In Uae is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis In Uae, Cialis In Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis In Uae.

Side effects and overdose

Due to the well-studied experience of Cialis In Uae, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Pharmacokinetics

The pharmacokinetics of Cialis In Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis In Uae in persons without erectile dysfunction. Absorption After taking Cialis In Uae inside Buy Cialis Johannesburg is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis In Uae does not depend on the meal, so Cialis In Uae can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Cialis In Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Cialis In Uae 1 time/day. The average Vd is about 63 liters, which indicates that Cialis Generico Online Mexico is distributed in the tissues of the body. The plasma protein binding of Cialis In Uae at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Cialis In Uae is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis In Uae. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Cialis Online Kopen Belgie when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis 5 Mg Online Italia is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Cialis 5mg Daily Buy Online when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis In Uae (AUC), patients with severe renal insufficiency are not recommended to use Cialis In Uae. The pharmacokinetics of Cialis In Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis In Uae to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Buy Cialis In Makati. In patients with diabetes mellitus during the use of Cialis In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Effect of Cialis In Uae on other drugs

It is known that Cialis Super Active Online Australia increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis In Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis In Uae in patients receiving nitrates is contraindicated.

Cialis In Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Kaufen Online Rezeptfrei does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis In Uae does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis 20 Mg Price Uae does not affect the action of warfarin against PV.

Cialis In Uae does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis In Uae has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Buy Cialis Johannesburg should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis In Uae in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis In Uae with doxazosin is contraindicated. When using Cialis In Uae healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Buy Cialis Discount did not affect the concentration of alcohol, nor did alcohol affect the concentration of Comprar Cialis Online Em Portugal. At high doses of alcohol (0.7 g/kg), Cialis Online Kaufen Schweiz did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis In Uae in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis In Uae has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

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