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Cialis Tablets In Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Tablets In Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Tablets In Uae reduced the rate of absorption of the latter without changing the AUC. Cialis Tablets In Uae enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tablets In Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Tablets In Uae in patients receiving nitrates is contraindicated


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Information

Pharmacokinetics

The pharmacokinetics of Cialis Tablets In Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Tablets In Uae in persons without erectile dysfunction.

Suction

After taking Cialis Tablets In Uae inside Cialis Tablets In Uae is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Tablets In Uae does not depend on the meal, so Cialis Tablets In Uae® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Buy Cialis Jakarta in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis Tablets In Uae 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Tablets In Uae is distributed in the tissues of the body.

The plasma protein binding of Cialis Tablets In Uae at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis Tablets In Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Tablets In Uae. Therefore, the concentration of this metabolite is not clinically significant.

Breeding

In healthy individuals, the average clearance of Cialis Tablets In Uae when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Tablets In Uae is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Tablets In Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Online San Marino (AUC), patients with severe renal insufficiency are not recommended to use Cialis Farmacia Online España®.

The pharmacokinetics of Cialis Tablets In Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Cialis Over The Counter Usa Cialis Tablets In Uae® patients with severe liver failure must first assess the risk and benefit of Cialis In Uae.

In patients with diabetes mellitus during the use of Cialis Tablets In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Dosage and administration

Inside. Use of Cialis Tablets In Uae Cialis Tablets In Uae according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Tablets In Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Tablets In Uae. The maximum daily dose of Cialis Tablets In Uae is 20 mg. the Use of Cialis Tablets In Uae according to the indication of BPH or ED/BPH. The recommended dose of Cialis Tablets In Uae when used once a day is 5 mg; Cialis Tablets In Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Kupovina Online is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Tablets In Uae at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Buy Cialis Over The Counter Uk in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Can You Buy Cialis Over The Counter Uk practically displayed.

Interaction with other drugs

Cialis Tablets In Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis 20mg Price In Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Tablets In Uae reduced the rate of absorption of the latter without changing the AUC. Buy Cialis Miami enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tablets In Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Generico Online Italia in patients receiving nitrates is contraindicated

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Tablets In Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Tablets In Uae is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Tablets In Uae, Cialis Tablets In Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Tablets In Uae.

Side effects and overdose

Due to the well-studied experience of Comprar Cialis Online Entrega 24 Horas, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Effect of Cialis Tablets In Uae on other drugs

It is known that Cialis Tablets In Uae increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Tablets In Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Buy Cialis Denmark in patients receiving nitrates is contraindicated.

Cialis Tablets In Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Online Kopen Belgie does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Tablets In Uae does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Tablets In Uae does not affect the action of warfarin against PV.

Buy Cialis In Tokyo does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Online San Marino has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis Tablets In Uae should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Online Consegna Veloce in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Tablet Price In Uae with doxazosin is contraindicated. When using Cialis Tablets In Uae healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Cialis Tablets In Uae did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Tablets In Uae. At high doses of alcohol (0.7 g/kg), Cialis Online Kaufen Ohne Rezept did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis Generico Online Miglior Prezzo in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis 20 Mg Price Uae has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

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