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Pharmacokinetics

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Cialis Online Consegna Veloce for the treatment of erectile dysfunction. Cialis Online Farmacia Italiana is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Uae Price leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Uae Price has no effect in the absence of sexual arousal.

In vitro studies have shown that Where Can You Buy Cialis Over The Counter is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Uae Price on PDE5 is more active than on other PDES. Buy Cialis Miami is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Online Bestellen Erfahrungsberichte is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis Uae Price is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Uae Price is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis Uae Price improves erection and increases the possibility of a full sexual intercourse.

Where Can You Buy Cialis Over The Counter in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis Uae Price does not cause a significant change in heart rate. Cialis Veilig Online Kopen does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Cialis Uae Price on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis Uae Price on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Uae Price compared to placebo.

The efficacy and safety of Comprar Cialis Online Entrega 24 Horas (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Uae Price 1 time/day. In studies of the primary efficacy of Cialis Online Farmacia Italiana at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis Uae Price at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Effect of Cialis Uae Price on other drugs

It is known that Cialis Uae Price increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae Price on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Uae Price in patients receiving nitrates is contraindicated.

Cialis Uae Price does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Uae Price does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Uae Price does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Uae Price does not affect the action of warfarin against PV.

Cialis Generico Online Italia Consegna Veloce does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Uae Price has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis Uae Price should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Uae Price in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Uae Price with doxazosin is contraindicated. When using Cialis Legal Online Bestellen healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Cialis Uae Price did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Uae Price. At high doses of alcohol (0.7 g/kg), Cialis Uae Price did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis Uae Price in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis Uae Price has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Dosage and administration

Inside. Use of Cialis Uae Price Cialis Uae Price according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Buy Japan. The maximum daily dose of Buy Liquid Cialis is 20 mg. the Use of Cialis Uae Price according to the indication of BPH or ED/BPH. The recommended dose of Cialis Online Kaufen Legal when used once a day is 5 mg; Cialis Generico Online Mexico should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Uae Price is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Can You Buy Cialis Over The Counter Canada at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Online Italia Consegna Veloce in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Uae Price practically displayed.

Interaction with other drugs

Cialis Uae Price is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Uae Price. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Uae Price reduced the rate of absorption of the latter without changing the AUC. Cialis Uae Price enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Comprar Cialis Online Canada on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Uae Price in patients receiving nitrates is contraindicated

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