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The plasma protein binding of Cialis 10mg Price In Uae at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

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In patients with diabetes mellitus during the use of Cialis 10mg Price In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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Effect of other drugs on Cialis Uae

Cialis 10mg Price In Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Buy Cialis Over The Counter Canada in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis 10mg Price In Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis 10mg Price In Uae Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Can I Buy Cialis Over The Counter Uk in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis 10mg Price In Uae activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis 10mg Price In Uae (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis 10mg Price In Uae Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis 10mg Price In Uae in plasma.

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The safety and effectiveness of the combination of Cialis 10mg Price In Uae with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

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Mechanism of action

The active substance of Cialis 10mg Price In Uae is Where Can You Buy Cialis Over The Counter, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis 10mg Price In Uae.

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The duration of the generic Cialis 10mg Price In Uae reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Kaufen Online Rezeptfrei should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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