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Be sure to consult your doctor before taking Cialis Kaufen Online Rezeptfrei pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

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The main feature of Buy Cialis Johannesburg is the ability to restore an erection for 36 hours after taking the pill, which will occur only with sexual arousal. That allows partners not to adapt to a certain time of Buy Cialis Johannesburg, and lead a normal life before the natural desire. In addition, the effectiveness of Buy Cialis Johannesburg will not affect a hearty dinner or drunk alcohol, which is also a definite plus for men of any age.

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Tablets are used inside and washed down with water, regardless of the meal. The minimum time before presumable sexual intercourse has to make 20 minutes. Most often, doctors recommend a dose of 20 mg. After that, for 36 hours, you can at any moment be in full sexual readiness. The maximum frequency of admission should not exceed 1 time per day. For the elderly, no changes in the dosage and application does not exist.

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After taking Buy Cialis Johannesburg inside Buy Cialis Johannesburg is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Online Farmacia Italiana does not depend on the meal, so Buy Cialis Johannesburg® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Buy Malaysia in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

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Css in plasma are attained within 5 days while taking Buy Cialis Johannesburg 1 time/day.

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The plasma protein binding of Buy Cialis Johannesburg at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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In healthy individuals, the average clearance of Buy Cialis Johannesburg when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Buy Cialis Johannesburg is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Buy Cialis Johannesburg when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Buy Cialis Johannesburg (AUC), patients with severe renal insufficiency are not recommended to use Buy Cialis Johannesburg®.

The pharmacokinetics of Buy Liquid Cialis in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Cialis Johannesburg Buy Cialis Johannesburg® patients with severe liver failure must first assess the risk and benefit of Buy Cialis Johannesburg.

In patients with diabetes mellitus during the use of Buy Cialis Discount AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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Buy Cialis Johannesburg for the treatment of erectile dysfunction. Buy Cialis Johannesburg is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Cost In Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Buy Cialis Johannesburg has no effect in the absence of sexual arousal.

In vitro studies have shown that Buy Cialis Johannesburg is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Cost In Uae on PDE5 is more active than on other PDES. Cialis Online Kaufen Forum is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Cialis Johannesburg is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Buy Cialis Johannesburg is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Buy Cialis Johannesburg is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Buy Cialis Johannesburg improves erection and increases the possibility of a full sexual intercourse.

Buy Cialis Johannesburg in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Buy Cialis Johannesburg does not cause a significant change in heart rate. Buy Cialis Johannesburg does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Buy Cialis Johannesburg on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Buy Cialis Johannesburg on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Online Consegna Veloce compared to placebo.

The efficacy and safety of Buy Cialis Johannesburg (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Buy Cialis Johannesburg 1 time/day. In studies of the primary efficacy of Buy Cialis Johannesburg at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Buy Cialis Johannesburg at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

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