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Cialis 20mg Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis 20mg Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis 20mg Uae reduced the rate of absorption of the latter without changing the AUC. Cialis 20mg Uae enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis 20mg Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated


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Information

Effect of other drugs on Cialis 20mg Uae

Cialis 20mg Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Kaufen Online Rezeptfrei in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Farmacia Online España Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis 20mg Uae in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Buy Cialis Over The Counter Usa activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis 20mg Uae (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Online Italia Consegna Veloce Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Comprar Cialis Online En Usa in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis 20mg Uae reduces the rate of absorption of Cialis 20mg Uae without changing the area under the pharmacokinetic curve for Cialis Online Miglior Prezzo. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Can I Buy Cialis Over The Counter Australia.

The safety and effectiveness of the combination of Cialis 20mg Uae with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis 20mg Uae does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Pharmacokinetics

The pharmacokinetics of Cialis 20mg Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis 20mg Uae in persons without erectile dysfunction. Absorption After taking Cialis 20mg Uae inside Cialis 20mg Uae is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis 20mg Uae does not depend on the meal, so Cialis 20mg Uae can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Cialis 20mg Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Cialis 20mg Uae 1 time/day. The average Vd is about 63 liters, which indicates that Cialis 20mg Uae is distributed in the tissues of the body. The plasma protein binding of Cialis 20mg Uae at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Cialis 20mg Uae is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis 20mg Uae. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Buy Cialis Taiwan when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis 20mg Uae is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Cialis 20mg Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Comprar Cialis Online En Usa (AUC), patients with severe renal insufficiency are not recommended to use Cialis 20mg Uae. The pharmacokinetics of Cialis 20mg Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis 20mg Uae to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Cialis 20mg Uae. In patients with diabetes mellitus during the use of Cialis 20mg Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Pharmacokinetics

The pharmacokinetics of Cialis Online Miglior Prezzo in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis 20mg Uae in persons without erectile dysfunction.

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After taking Cialis 20mg Uae inside Cialis 20mg Uae is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis 20mg Uae does not depend on the meal, so Cialis 20mg Uae® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Buy South Africa in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis 20mg Uae 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis 20mg Uae is distributed in the tissues of the body.

The plasma protein binding of Cialis 20mg Uae at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis 20mg Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis 20mg Uae. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Online Kopen Ervaringen when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis 20mg Uae is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis 20mg Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis 20mg Uae (AUC), patients with severe renal insufficiency are not recommended to use Cialis 20mg Uae®.

The pharmacokinetics of Cialis 20mg Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis 20mg Uae Comprare Cialis Online è Legale® patients with severe liver failure must first assess the risk and benefit of Cialis 20mg Uae.

In patients with diabetes mellitus during the use of Cialis 20mg Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Effect of Cialis Online Kaufen Ohne Rezept on other drugs

It is known that Cialis 20mg Uae increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis 20mg Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated.

Cialis 20mg Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis 20mg Uae does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Generico Online Recensioni does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis 20mg Uae does not affect the action of warfarin against PV.

Cialis 20mg Uae does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis 20mg Uae has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis 20mg Uae should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis 20mg Uae in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis 20mg Uae with doxazosin is contraindicated. When using Cialis 20mg Uae healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Viagra Cialis Vendita Online did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Super Active Online Australia. At high doses of alcohol (0.7 g/kg), Cialis 20mg Uae did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis 20mg Uae in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis 20mg Uae has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

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