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  • The body, which is sensitive to any of the components of Buy Cialis Johannesburg, Buy Cialis Johannesburg is strictly contraindicated.
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  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Buy Cialis Johannesburg.

Side effects and overdose

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  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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On sale Buy Cialis Johannesburg first appeared in 2003 and immediately attracted the attention of the target audience: at that time, many wanted to buy not viagra and Buy Cialis Johannesburg. As a result, the sale soon appeared exact copies of Cialis Online Farmacia Italiana — generics, which accurately repeated the composition of the original substance, but cost much less.

Whether it is possible to buy generic Can You Buy Cialis Over The Counter Uk, whether it will harm health — similar thoughts arise in many who want to buy Buy Cialis Johannesburg. I must say that such doubts are in vain, as Cialis Buy Malaysia-copy passes the same tests and tests as the original. In addition, the branded drug is quite expensive, and not everyone can buy it.

The effect on the body Buy Cialis Johannesburg is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Cialis Generico Online Mexico is based on the properties of Buy Cialis Johannesburg, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

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Dosage and administration

Inside. Use of Buy Cialis Johannesburg Buy Cialis Miami according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Online Bestellen Erfahrungsberichte at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Johannesburg. The maximum daily dose of Buy Cialis Johannesburg is 20 mg. the Use of Buy Cialis Johannesburg according to the indication of BPH or ED/BPH. The recommended dose of Where Can You Buy Cialis Over The Counter when used once a day is 5 mg; Buy Cialis Johannesburg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Veilig Online Kopen is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Buy Cialis Johannesburg at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Buy Cialis Johannesburg in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Buy Cialis Johannesburg practically displayed.

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Comprar Cialis Online Entrega 24 Horas is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Buy Cialis Johannesburg. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Online Farmacia Italiana reduced the rate of absorption of the latter without changing the AUC. Buy Cialis Johannesburg enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Buy Cialis Johannesburg on the metabolism of nitric oxide and cGMP. Therefore, the use of Buy Cialis Johannesburg in patients receiving nitrates is contraindicated

Pharmacokinetics

The pharmacokinetics of Buy Cialis Johannesburg in patients with erectile dysfunction is similar to the pharmacokinetics of Buy Cialis Johannesburg in persons without erectile dysfunction.

Suction

After taking Buy Cialis Johannesburg inside Buy Cialis Johannesburg is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Buy Cialis Johannesburg does not depend on the meal, so Buy Cialis Johannesburg® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Generico Online Italia Consegna Veloce in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Buy Cialis Johannesburg 1 time/day.

The average Vd is about 63 liters, which indicates that Buy Cialis Johannesburg is distributed in the tissues of the body.

The plasma protein binding of Buy Cialis Johannesburg at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Buy Cialis Johannesburg is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Legal Online Bestellen. Therefore, the concentration of this metabolite is not clinically significant.

Breeding

In healthy individuals, the average clearance of Buy Cialis Johannesburg when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Buy Cialis Johannesburg is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Buy Cialis Johannesburg when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Buy Cialis Johannesburg (AUC), patients with severe renal insufficiency are not recommended to use Buy Cialis Johannesburg®.

The pharmacokinetics of Buy Cialis Johannesburg in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Cialis Johannesburg Buy Cialis Johannesburg® patients with severe liver failure must first assess the risk and benefit of Cialis Buy Japan.

In patients with diabetes mellitus during the use of Buy Liquid Cialis AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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