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Information

Clinical pharmacology

Cialis In Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Farmacia Online España leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Can You Buy Cialis Over The Counter Usa has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Buy Dubai is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis In Uae on PDE-5 is more active than on other PDES. Cialis In Uae is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis In Uae is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis In Uae is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Generico Online Italia is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis In Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis In Uae in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Can I Buy Cialis Over The Counter Uk does not cause a significant change in heart rate.

Cialis In Uae does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis In Uae on visual acuity, electroretinogram, intraocular pressure and pupil size.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Tablets In Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Buy Cialis Over The Counter Usa is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis In Uae, Cialis 20 Mg Price Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis In Uae.

Side effects and overdose

Due to the well-studied experience of Cialis In Uae, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Buy South Africa on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Lilly Cialis Uk compared to placebo.

The efficacy and safety of Cialis 10mg Price In Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis In Uae 1 time per day. In studies of the primary efficacy of Comprar Cialis Online En Usa at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis In Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Comprar Cialis Online Canada in patients with BPH — inhibition of PDE-5 Cialis In Uae, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Can I Buy Cialis Over The Counter Cialis In Uae according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis In Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Online Kaufen Forum. The maximum daily dose of Cialis In Uae is 20 mg.

The use of Cialis Kaufen Online Rezeptfrei Cialis Online Kopen Belgie for indication of BPH or ED/BPH.The recommended dose of Cialis In Uae Price when used once a day is 5 mg; Cialis Online Spedizione Veloce should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis In Uae once a day is not recommended.

Mechanism of action

The active substance of Cialis In Uae is Cialis In Uae, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis In Uae.

Rules of admission

The duration of the generic Cialis Kupovina Online reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis In Uae should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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