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Effect of other drugs on Cialis Generico Online Italia Consegna Veloce

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After taking Cialis In Uae Price inside Cialis In Uae Price is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis In Uae Price does not depend on the meal, so Cialis In Uae Price® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis In Uae Price in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

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Css in plasma are attained within 5 days while taking Cialis In Uae Price 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis In Uae Price is distributed in the tissues of the body.

The plasma protein binding of Cialis In Uae Price at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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Cialis In Uae Price is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Buy Cialis Johannesburg. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis In Uae Price when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis In Uae Price is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis In Uae Price when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis In Uae Price (AUC), patients with severe renal insufficiency are not recommended to use Cialis Generico Online Mexico®.

The pharmacokinetics of Cialis In Uae Price in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis In Uae Price Cialis In Uae Price® patients with severe liver failure must first assess the risk and benefit of Cialis Online Kopen Belgie.

In patients with diabetes mellitus during the use of Cialis 5 Mg Online Italia AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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