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Information

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After taking Cialis Buy Malaysia inside Cialis Generico Online Sicuro is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Buy Malaysia does not depend on the meal, so Cialis Buy Malaysia® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Buy Malaysia in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis De Vanzare Online 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Buy Malaysia is distributed in the tissues of the body.

The plasma protein binding of Cialis Buy Malaysia at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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In healthy individuals, the average clearance of Cialis Buy Malaysia when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Buy Malaysia is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Buy Malaysia when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Buy Cialis Over The Counter Uk (AUC), patients with severe renal insufficiency are not recommended to use Buy Cialis Medication®.

The pharmacokinetics of Cialis Buy Malaysia in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Can I Buy Cialis Over The Counter Cialis Buy Malaysia® patients with severe liver failure must first assess the risk and benefit of Cialis Buy Malaysia.

In patients with diabetes mellitus during the use of Cialis De Vanzare Online AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Tablets In Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Buy Malaysia is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Buy Malaysia, Cialis Buy Malaysia is strictly contraindicated.
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  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Buy Cialis Super Active.

Side effects and overdose

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Effect of Cialis Buy Malaysia on other drugs

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Cialis Price In Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Buy Malaysia does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Can You Buy Cialis Over The Counter Canada does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Buy Malaysia does not affect the action of warfarin against PV.

Cialis Buy Malaysia does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Buy Malaysia has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis Buy Malaysia should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Online Kaufen Schweiz in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Online Kaufen österreich with doxazosin is contraindicated. When using Cialis Online Miglior Prezzo healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Cialis Buy Malaysia did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Buy Malaysia. At high doses of alcohol (0.7 g/kg), Cialis Online Kopen Ervaringen did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis Buy Malaysia in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis Buy Malaysia has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

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