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Cialis Generico Online Italia Consegna Veloce for the treatment of erectile dysfunction. Cialis Generico Online Italia Consegna Veloce is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Generico Online Italia Consegna Veloce leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Generico Online Italia Consegna Veloce has no effect in the absence of sexual arousal.


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Information

Pharmacological action

Cialis 20mg Uae for the treatment of erectile dysfunction. Cialis Generico Online Recensioni is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis 20mg Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Veilig Online Kopen has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis 20mg Uae is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis 20mg Uae on PDE5 is more active than on other PDES. Cialis 20mg Uae is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Cialis Miami is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis 20mg Uae is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Buy Cialis Over The Counter Usa is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis 20mg Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis 20mg Uae in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis 20mg Uae does not cause a significant change in heart rate. Cialis 20mg Uae does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Cialis 20mg Uae on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis 20mg Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis 20mg Uae compared to placebo.

The efficacy and safety of Cialis 20mg Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis 20mg Uae 1 time/day. In studies of the primary efficacy of Buy Cialis Medication at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis 20mg Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis 20mg Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Veilig Online Kopen is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis 20mg Uae, Cialis 20mg Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis 20mg Uae.

Side effects and overdose

Due to the well-studied experience of Can You Buy Cialis Over The Counter Canada, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Mechanism of action

The active substance of Comprar Cialis Online Em Portugal is Cialis 20mg Uae, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis 20mg Uae.

Rules of admission

The duration of the generic Cialis Online Kaufen Ohne Rezept Erfahrungen reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Buy Cialis Taiwan should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

To sum up: buy Cialis 20mg Uae (Cialis 20mg Uae) should be because

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Effect of other drugs on Cialis 20mg Uae

Comprar Cialis Online Canada is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis 20mg Uae Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Buy Cialis Discount in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis 20mg Uae activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Buy Cialis Miami (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis 20mg Uae Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Can I Buy Cialis Over The Counter Uk in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis 20mg Uae reduces the rate of absorption of Cialis 20mg Uae without changing the area under the pharmacokinetic curve for Cialis 20mg Uae. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis 20mg Uae.

The safety and effectiveness of the combination of Cialis 20mg Uae with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis 20mg Uae does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

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