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Dosage and administration

Inside. Use of Buy Cialis Discount Buy Cialis Over The Counter Uk according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Can You Buy Cialis Over The Counter Uk at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Discount. The maximum daily dose of Cialis 20mg Price In Uae is 20 mg. the Use of Buy Cialis Discount according to the indication of BPH or ED/BPH. The recommended dose of Buy Cialis Miami when used once a day is 5 mg; Buy Cialis Discount should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Generico Online Italia is contraindicated.

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Interaction with other drugs

Buy Cialis Discount is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Buy Cialis Discount. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Comprar Cialis Online Entrega 24 Horas reduced the rate of absorption of the latter without changing the AUC. Buy Cialis Discount enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Buy Cialis Discount on the metabolism of nitric oxide and cGMP. Therefore, the use of Buy Cialis Discount in patients receiving nitrates is contraindicated

Clinical pharmacology

Buy Cialis Denmark is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Buy Cialis Discount leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Online Kopen Belgie has no effect in the absence of sexual arousal.

In vitro studies have shown that Buy Cialis Discount is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Buy Cialis Discount on PDE-5 is more active than on other PDES. Buy Cialis In Tokyo is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Online San Marino is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Buy Cialis Discount is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Online Consegna Veloce is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

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Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Generico Online Miglior Prezzo on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis 20 Mg Price Uae compared to placebo.

The efficacy and safety of Buy Cialis Discount (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Buy Japan 1 time per day. In studies of the primary efficacy of Buy Cialis Discount at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Buy Cialis Discount at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

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The use of Buy Cialis Discount Cialis Online Italia Consegna Veloce according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

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