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Information

Pharmacological action

Buy Cialis Denmark for the treatment of erectile dysfunction. Cialis Uae is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Uae is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Uae on PDE5 is more active than on other PDES. Cialis Uae is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Uae is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis Uae is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Uae is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis Uae improves erection and increases the possibility of a full sexual intercourse.

Buy Cialis Denmark in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis Uae does not cause a significant change in heart rate. Cialis Buy Pakistan does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Cialis Uae on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Generico Online Mexico compared to placebo.

The efficacy and safety of Cialis Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Online Snabb Leverans 1 time/day. In studies of the primary efficacy of Cialis Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Buy Cialis Over The Counter at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Peculiar properties

On sale Cialis Uae first appeared in 2003 and immediately attracted the attention of the target audience: at that time, many wanted to buy not viagra and Cialis 5mg Daily Buy Online. As a result, the sale soon appeared exact copies of Cialis Uae — generics, which accurately repeated the composition of the original substance, but cost much less.

Whether it is possible to buy generic Cialis Uae, whether it will harm health — similar thoughts arise in many who want to buy Cialis Uae. I must say that such doubts are in vain, as Cialis Uae-copy passes the same tests and tests as the original. In addition, the branded drug is quite expensive, and not everyone can buy it.

The effect on the body Cialis Uae is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Cialis Uae is based on the properties of Cialis Uae, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

The long-term effect of Cialis Uae allows you not to worry about what you need to do everything in time: taking a pill, a man will be able to quality sexual intercourse within 1.5 days.

What else is the argument for purchasing Cialis Online Bestellen Erfahrungsberichte?

Many men want to buy generic Cialis Ireland To Buy, not viagra, as in parallel with taking the pill you can drink alcohol and eat (even fat) without any health consequences. In addition, Buy Cialis Over The Counter In Canada does not serve as a reason for excitement, but only normalizes erectile function, allowing men to lead a full sexual life.

In addition, clinical trials have shown that men who underwent therapeutic treatment with Cialis Uae, noticed an improvement in erection and after taking generic.

Mechanism of action

The active substance of Cialis Uae is Cialis Uae, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis Kaufen Online Rezeptfrei.

Rules of admission

The duration of the generic Cialis Online Kopen Belgie reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Can You Buy Cialis Over The Counter Yet should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Effect of other drugs on Comprar Cialis Online Mexico

Cialis Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Buy Cialis Johannesburg in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Can You Buy Cialis Over The Counter Uk Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Buy Cialis Denmark in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Uae activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Uae (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Uae Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Uae in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Uae reduces the rate of absorption of Cialis Uae without changing the area under the pharmacokinetic curve for Cialis Online Kaufen Ohne Rezept. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Uae.

The safety and effectiveness of the combination of Cialis Uae with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

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