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The pharmacokinetics of Cialis 20mg Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis 20mg Uae Cialis 20mg Uae® patients with severe liver failure must first assess the risk and benefit of Cialis 20mg Uae.


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Information

Pharmacological action

Cialis 20mg Uae for the treatment of erectile dysfunction. Viagra Cialis Vendita Online is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Buy Cialis Taiwan leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis 20mg Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis 20mg Uae is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Online Kaufen Ohne Rezept on PDE5 is more active than on other PDES. Cialis 20mg Uae is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Malaysia Where To Buy is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis 5mg Price In Uae is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis 20mg Uae is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis 20mg Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis 20mg Uae in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis 20mg Uae does not cause a significant change in heart rate. Cialis 20mg Uae does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Comprar Cialis Online En Usa on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis 20mg Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Where Can You Buy Cialis Over The Counter compared to placebo.

The efficacy and safety of Buy Cialis Super Active (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis 20mg Uae 1 time/day. In studies of the primary efficacy of Cialis 20mg Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis 20mg Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Effect of other drugs on Cialis Generico Online Recensioni

Cialis 20mg Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Buy Malaysia Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Online Kaufen Schweiz in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis 20mg Uae activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis 20mg Uae (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis 20mg Uae Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Generico Online Mexico in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis 20mg Uae reduces the rate of absorption of Cialis Kupovina Online without changing the area under the pharmacokinetic curve for Cialis 20mg Uae. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis 20mg Uae.

The safety and effectiveness of the combination of Cialis 20mg Uae with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis 20mg Uae does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Dosage and administration

Inside. Use of Cialis 20mg Uae Cialis 20mg Uae according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis 20mg Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Where Can I Buy Cialis Over The Counter Usa. The maximum daily dose of Cialis 20mg Uae is 20 mg. the Use of Cialis 20mg Uae according to the indication of BPH or ED/BPH. The recommended dose of Cialis 20mg Uae when used once a day is 5 mg; Buy Cialis Over The Counter Canada should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis 20mg Uae is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis 20mg Uae at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis 20mg Uae in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Buy Cialis Discount practically displayed.

Interaction with other drugs

Cialis 20mg Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis 20mg Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis 20mg Uae reduced the rate of absorption of the latter without changing the AUC. Buy Cialis Denmark enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis 20mg Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated

Peculiar properties

On sale Cialis 20mg Uae first appeared in 2003 and immediately attracted the attention of the target audience: at that time, many wanted to buy not viagra and Can You Buy Cialis Over The Counter. As a result, the sale soon appeared exact copies of Cialis 20mg Uae — generics, which accurately repeated the composition of the original substance, but cost much less.

Whether it is possible to buy generic Cialis 20mg Uae, whether it will harm health — similar thoughts arise in many who want to buy Cialis 20mg Uae. I must say that such doubts are in vain, as Cialis 20mg Uae-copy passes the same tests and tests as the original. In addition, the branded drug is quite expensive, and not everyone can buy it.

The effect on the body Cialis Online Kaufen Erfahrungen is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Comprar Cialis Online Em Portugal is based on the properties of Cialis 20mg Uae, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

The long-term effect of Cialis Online Kaufen Forum allows you not to worry about what you need to do everything in time: taking a pill, a man will be able to quality sexual intercourse within 1.5 days.

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