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The pharmacokinetics of Cialis Uae Price in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Uae Price Cialis Uae Price® patients with severe liver failure must first assess the risk and benefit of Cialis Uae Price.


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Information

Dosage and administration

Inside. Use of Cialis 20mg Price In Uae Cialis Uae Price according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Online Kopen Nederland. The maximum daily dose of Cialis Uae Price is 20 mg. the Use of Can You Buy Cialis Over The Counter Uk according to the indication of BPH or ED/BPH. The recommended dose of Buy Cialis Denmark when used once a day is 5 mg; Cialis Uae Price should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Can I Buy Cialis Over The Counter Uk is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis 5 Mg Online Italia at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Uae Price in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Uae Price practically displayed.

Interaction with other drugs

Cialis Uae Price is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Uae Price. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Uae Price reduced the rate of absorption of the latter without changing the AUC. Cialis Uae Price enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae Price on the metabolism of nitric oxide and cGMP. Therefore, the use of Can I Buy Cialis Over The Counter Canada in patients receiving nitrates is contraindicated

Effect of other drugs on Cialis Uae Price

Cialis Online Consegna Veloce is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Uae Price in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Uae Price in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Uae Price Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Uae Price in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Uae Price activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Buy Cialis Super Active (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Uae Price Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Uae Price in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Online Snabb Leverans reduces the rate of absorption of Cialis Uae Price without changing the area under the pharmacokinetic curve for Cialis Farmacia Online España. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Online Bestellen Erfahrungsberichte.

The safety and effectiveness of the combination of Cialis Uae Price with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis Uae Price does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Mechanism of action

The active substance of Cialis Uae Price is Cialis Uae Price, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis Uae Price.

Rules of admission

The duration of the generic Cialis Uae Price reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Uae Price should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Cialis Uae Price is a drug that has long gained popularity in men who have a weak or unstable erection. A huge number of clinical studies and experiments were conducted, in which several thousand people with erectile dysfunction participated. The effectiveness of Cialis Uae Price was 81%, this percentage of men was able to fully restore the "normal" erection, the rest got rid of their ailments, depending on the degree of complexity of the disease. Agree, this is an amazing result!

The main feature of Cialis Uae Price is the ability to restore an erection for 36 hours after taking the pill, which will occur only with sexual arousal. That allows partners not to adapt to a certain time of Cialis Generico Online Mexico, and lead a normal life before the natural desire. In addition, the effectiveness of Cialis Uae Price will not affect a hearty dinner or drunk alcohol, which is also a definite plus for men of any age.

Action of preparation

We all understand that the main effect of the action of Cialis Uae Price should be only one – increasing potency in men. This is exactly what happens after the use of Cialis Uae Price, with sexual arousal: the blood vessels of the penis expand, after which it receives a more enhanced blood flow, thereby creating a "normal" erection. A noticeable improvement in potency can be observed within 20 minutes after the use of Cialis Online Kopen Belgie.

Application and dosage

Tablets are used inside and washed down with water, regardless of the meal. The minimum time before presumable sexual intercourse has to make 20 minutes. Most often, doctors recommend a dose of 20 mg. After that, for 36 hours, you can at any moment be in full sexual readiness. The maximum frequency of admission should not exceed 1 time per day. For the elderly, no changes in the dosage and application does not exist.

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