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Cialis Uae Price is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Uae Price. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Uae Price reduced the rate of absorption of the latter without changing the AUC. Cialis Uae Price enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae Price on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Uae Price in patients receiving nitrates is contraindicated


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Information

Effect of Cialis Online Kaufen österreich on other drugs

It is known that Cialis Uae Price increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae Price on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Uae Price in patients receiving nitrates is contraindicated.

Buy Cialis Denmark does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Uae Price does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Uae Price does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Uae Price does not affect the action of warfarin against PV.

Cialis Uae Price does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Uae Price has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Buy Cialis Miami should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Uae Price in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Uae Price with doxazosin is contraindicated. When using Cialis Online Kopen Nederland healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Cialis Uae Price did not affect the concentration of alcohol, nor did alcohol affect the concentration of Comprar Cialis Online En Usa. At high doses of alcohol (0.7 g/kg), Cialis Uae Price did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis Uae Price in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis Online Bestellen Erfahrungsberichte has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Pharmacological action

Cialis Online Kaufen Ohne Rezept Erfahrungen for the treatment of erectile dysfunction. Cialis Uae Price is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Generico Online Italia Consegna Veloce leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Uae Price has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Uae Price is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Uae Price on PDE5 is more active than on other PDES. Cialis Uae Price is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Uae Price is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Comprar Cialis Online Mexico is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Uae Price is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis Uae Price improves erection and increases the possibility of a full sexual intercourse.

Cialis Uae Price in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis Uae Price does not cause a significant change in heart rate. Cialis Uae Price does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Cialis Tablets In Uae on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis Uae Price on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Uae Price compared to placebo.

The efficacy and safety of Cialis Uae Price (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Uae Price 1 time/day. In studies of the primary efficacy of Cialis Uae Price at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Can You Buy Cialis Over The Counter at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Uae Price pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Uae Price is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Online Kaufen Erfahrungen, Buy Cialis Johannesburg is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Uae Price.

Side effects and overdose

Due to the well-studied experience of Cialis Uae Price, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Mechanism of action

The active substance of Cialis Uae Price is Cialis Uae Price, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis Uae Price.

Rules of admission

The duration of the generic Cialis Uae Price reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Uae Price should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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