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The pharmacokinetics of Cialis Uae Price in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Uae Price in persons without erectile dysfunction. Absorption After taking Cialis Uae Price inside Cialis Uae Price is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Uae Price does not depend on the meal, so Cialis Uae Price can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.


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Information

Clinical pharmacology

Cialis Online Kaufen österreich is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Uae Price leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Uae Price has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Uae Price is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Buy Cialis Denmark on PDE-5 is more active than on other PDES. Cialis Uae Price is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Uae Price is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis Uae Price is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Uae Price is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Uae Price improves erection and increases the possibility of a full sexual intercourse.

Buy Cialis Miami in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Uae Price does not cause a significant change in heart rate.

Cialis Uae Price does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Online Kopen Nederland on visual acuity, electroretinogram, intraocular pressure and pupil size.

Pharmacokinetics

The pharmacokinetics of Cialis Uae Price in patients with erectile dysfunction is similar to the pharmacokinetics of Comprar Cialis Online En Usa in persons without erectile dysfunction.

Suction

After taking Cialis Uae Price inside Cialis Uae Price is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Online Bestellen Erfahrungsberichte does not depend on the meal, so Cialis Online Kaufen Ohne Rezept Erfahrungen® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Uae Price in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis Generico Online Italia Consegna Veloce 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Uae Price is distributed in the tissues of the body.

The plasma protein binding of Cialis Uae Price at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis Uae Price is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Uae Price. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Uae Price when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Comprar Cialis Online Mexico is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Uae Price when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Uae Price (AUC), patients with severe renal insufficiency are not recommended to use Cialis Uae Price®.

The pharmacokinetics of Cialis Uae Price in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Uae Price Cialis Tablets In Uae® patients with severe liver failure must first assess the risk and benefit of Cialis Uae Price.

In patients with diabetes mellitus during the use of Cialis Uae Price AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Dosage and administration

Inside. Use of Cialis Uae Price Cialis Uae Price according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Can You Buy Cialis Over The Counter. The maximum daily dose of Cialis Uae Price is 20 mg. the Use of Cialis Uae Price according to the indication of BPH or ED/BPH. The recommended dose of Cialis Online Kaufen Erfahrungen when used once a day is 5 mg; Buy Cialis Johannesburg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Uae Price is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Uae Price at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Uae Price in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Uae Price practically displayed.

Interaction with other drugs

Cialis Uae Price is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Uae Price. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Uae Price reduced the rate of absorption of the latter without changing the AUC. Cialis Uae Price enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Buy Cialis In Makati on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Uae Price in patients receiving nitrates is contraindicated

Effect of other drugs on Cialis Online Kaufen Forum

Cialis Uae Price is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Uae Price in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis Uae Price in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Uae Price Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Online Kaufen Ohne Rezept in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Buy Cialis Medication activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Uae Price (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Uae Price Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Uae Price in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Uae Price reduces the rate of absorption of Cialis Uae Price without changing the area under the pharmacokinetic curve for Cialis Tablets In Uae. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Uae Price.

The safety and effectiveness of the combination of Cialis Uae Price with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis Uae Price does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

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