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Information

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Buy Malaysia on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Buy Malaysia compared to placebo.

The efficacy and safety of Cialis Buy Malaysia (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Buy Malaysia 1 time per day. In studies of the primary efficacy of Cialis 20mg Price In Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Buy Malaysia at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Buy Malaysia in patients with BPH — inhibition of PDE-5 Cialis Buy Malaysia, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Buy Malaysia Cialis Buy Malaysia according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

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The use of Cialis Buy Malaysia Cialis Buy Malaysia for indication of BPH or ED/BPH.The recommended dose of Cialis Online Kaufen Schweiz when used once a day is 5 mg; Can You Buy Cialis Over The Counter Uk should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Can You Buy Cialis Over The Counter Yet once a day is not recommended.

Mechanism of action

The active substance of Cialis Buy Malaysia is Cialis Buy Malaysia, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

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Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Dosage and administration

Inside. Use of Cialis Buy Malaysia Buy Cialis Over The Counter Usa according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Buy Malaysia at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Online Italia Consegna Veloce. The maximum daily dose of Comprar Cialis Online En Usa is 20 mg. the Use of Cialis Buy Malaysia according to the indication of BPH or ED/BPH. The recommended dose of Cialis Buy Malaysia when used once a day is 5 mg; Cialis Online Miglior Prezzo should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Can I Buy Cialis Over The Counter Australia is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Buy Malaysia at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Buy Malaysia in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Buy Malaysia practically displayed.

Interaction with other drugs

Cialis Buy Malaysia is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Buy Malaysia. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Buy Malaysia reduced the rate of absorption of the latter without changing the AUC. Cialis Buy Malaysia enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Buy Malaysia on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Buy Malaysia in patients receiving nitrates is contraindicated

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