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Cialis 20mg Uae is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis 20mg Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis 20mg Uae reduced the rate of absorption of the latter without changing the AUC. Cialis 20mg Uae enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis 20mg Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated


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Information

Pharmacological action

Cialis 20mg Uae for the treatment of erectile dysfunction. Viagra Cialis Vendita Online is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Buy Cialis Taiwan leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis 20mg Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis 20mg Uae is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Online Kaufen Ohne Rezept on PDE5 is more active than on other PDES. Cialis 20mg Uae is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Malaysia Where To Buy is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis 5mg Price In Uae is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis 20mg Uae is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis 20mg Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis 20mg Uae in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis 20mg Uae does not cause a significant change in heart rate. Cialis 20mg Uae does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Comprar Cialis Online En Usa on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis 20mg Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Where Can You Buy Cialis Over The Counter compared to placebo.

The efficacy and safety of Buy Cialis Super Active (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis 20mg Uae 1 time/day. In studies of the primary efficacy of Cialis 20mg Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis 20mg Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Generico Online Recensioni pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis 20mg Uae is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis 20mg Uae, Cialis 20mg Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Buy Malaysia.

Side effects and overdose

Due to the well-studied experience of Cialis Online Kaufen Schweiz, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Mechanism of action

The active substance of Cialis 20mg Uae is Cialis 20mg Uae, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis 20mg Uae.

Rules of admission

The duration of the generic Cialis Generico Online Mexico reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis 20mg Uae should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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About Cialis 20mg Uae

Cialis 20mg Uae is a drug that has long gained popularity in men who have a weak or unstable erection. A huge number of clinical studies and experiments were conducted, in which several thousand people with erectile dysfunction participated. The effectiveness of Cialis 20mg Uae was 81%, this percentage of men was able to fully restore the "normal" erection, the rest got rid of their ailments, depending on the degree of complexity of the disease. Agree, this is an amazing result!

The main feature of Cialis 20mg Uae is the ability to restore an erection for 36 hours after taking the pill, which will occur only with sexual arousal. That allows partners not to adapt to a certain time of Cialis 20mg Uae, and lead a normal life before the natural desire. In addition, the effectiveness of Where Can I Buy Cialis Over The Counter Usa will not affect a hearty dinner or drunk alcohol, which is also a definite plus for men of any age.

Action of preparation

We all understand that the main effect of the action of Cialis 20mg Uae should be only one – increasing potency in men. This is exactly what happens after the use of Cialis 20mg Uae, with sexual arousal: the blood vessels of the penis expand, after which it receives a more enhanced blood flow, thereby creating a "normal" erection. A noticeable improvement in potency can be observed within 20 minutes after the use of Cialis 20mg Uae.

Application and dosage

Tablets are used inside and washed down with water, regardless of the meal. The minimum time before presumable sexual intercourse has to make 20 minutes. Most often, doctors recommend a dose of 20 mg. After that, for 36 hours, you can at any moment be in full sexual readiness. The maximum frequency of admission should not exceed 1 time per day. For the elderly, no changes in the dosage and application does not exist.

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