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The active substance of Cialis De Vanzare Online is Cialis Buy Malaysia, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis Buy Malaysia.

Rules of admission

The duration of the generic Cialis Buy Malaysia reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Buy Malaysia should be water.

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Effect of Cialis Buy Malaysia on other drugs

It is known that Cialis Online Kaufen Ohne Rezept increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Generico Online Miglior Prezzo on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis 20 Mg Price Uae in patients receiving nitrates is contraindicated.

Cialis Buy Malaysia does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Buy Japan does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

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Cialis Buy Malaysia does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Buy Malaysia has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis Buy Malaysia should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis Online Italia Consegna Veloce in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Buy Cialis Mumbai with doxazosin is contraindicated. When using Where Can You Buy Cialis Over The Counter healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Buy Lilly Cialis Uk did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Buy Malaysia. At high doses of alcohol (0.7 g/kg), Cialis Buy Malaysia did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Buy Cialis Over The Counter Canada in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis Buy Malaysia has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Clinical pharmacology

Cialis Buy Malaysia is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Legal Online Bestellen leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Buy Malaysia has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Buy Malaysia is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Buy Cialis Mumbai on PDE-5 is more active than on other PDES. Cialis Uae is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Buy Malaysia is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis Buy Malaysia is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Buy Malaysia is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis 20mg Price In Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis Buy Malaysia in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Buy Malaysia does not cause a significant change in heart rate.

Cialis Buy Malaysia does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Buy Malaysia on visual acuity, electroretinogram, intraocular pressure and pupil size.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Buy Malaysia pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

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Side effects and overdose

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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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