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Information

Effect of other drugs on Cialis Buy Dubai

Cialis Buy Dubai is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Buy Dubai in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis 20 Mg Price Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Buy Dubai Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Buy Cialis In Makati in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Online Kaufen Ohne Rezept activity.

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Clinical pharmacology

Cialis Buy Dubai is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Buy Dubai leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis 5 Mg Online Italia has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Buy Dubai is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Buy Dubai on PDE-5 is more active than on other PDES. Cialis Buy Dubai is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Buy Dubai is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis Buy Dubai is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Buy Dubai is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Buy Dubai improves erection and increases the possibility of a full sexual intercourse.

Cialis Buy Dubai in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Buy Dubai does not cause a significant change in heart rate.

Cialis Buy Dubai does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Buy Dubai on visual acuity, electroretinogram, intraocular pressure and pupil size.

About Cialis Buy Dubai

Cialis Buy Dubai is a drug that has long gained popularity in men who have a weak or unstable erection. A huge number of clinical studies and experiments were conducted, in which several thousand people with erectile dysfunction participated. The effectiveness of Cialis Buy Dubai was 81%, this percentage of men was able to fully restore the "normal" erection, the rest got rid of their ailments, depending on the degree of complexity of the disease. Agree, this is an amazing result!

The main feature of Cialis Online Bestellen Erfahrungen is the ability to restore an erection for 36 hours after taking the pill, which will occur only with sexual arousal. That allows partners not to adapt to a certain time of Cialis Buy Dubai, and lead a normal life before the natural desire. In addition, the effectiveness of Cialis Buy Dubai will not affect a hearty dinner or drunk alcohol, which is also a definite plus for men of any age.

Action of preparation

We all understand that the main effect of the action of Cialis Buy Dubai should be only one – increasing potency in men. This is exactly what happens after the use of Cialis 5mg Daily Buy Online, with sexual arousal: the blood vessels of the penis expand, after which it receives a more enhanced blood flow, thereby creating a "normal" erection. A noticeable improvement in potency can be observed within 20 minutes after the use of Cialis Buy Dubai.

Application and dosage

Tablets are used inside and washed down with water, regardless of the meal. The minimum time before presumable sexual intercourse has to make 20 minutes. Most often, doctors recommend a dose of 20 mg. After that, for 36 hours, you can at any moment be in full sexual readiness. The maximum frequency of admission should not exceed 1 time per day. For the elderly, no changes in the dosage and application does not exist.

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