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Information

Pharmacological action

Cialis In Uae for the treatment of erectile dysfunction. Cialis In Uae is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis In Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis In Uae has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Online Kaufen Erfahrungen is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Comprar Cialis Online Em Portugal on PDE5 is more active than on other PDES. Cialis In Uae is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Online Kaufen Forum is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis In Uae is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis In Uae is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Generic Cialis Online Sales improves erection and increases the possibility of a full sexual intercourse.

Buy Cialis In Dublin in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis Online Spedizione Veloce does not cause a significant change in heart rate. Cialis In Uae does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Buy Cialis Over The Counter Canada on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis In Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis In Uae compared to placebo.

The efficacy and safety of Cialis In Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis In Uae 1 time/day. In studies of the primary efficacy of Buy Cialis Miami at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis In Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Dosage and administration

Inside. Use of Cialis In Uae Cialis 5mg Price In Uae according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis In Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis In Uae. The maximum daily dose of Cialis In Uae is 20 mg. the Use of Cialis In Uae according to the indication of BPH or ED/BPH. The recommended dose of Buy Cialis In Makati when used once a day is 5 mg; Cialis Buy Japan should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Can I Buy Cialis Over The Counter Uk is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis In Uae at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Uae in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis In Uae practically displayed.

Interaction with other drugs

Buy Cialis Over The Counter Canada is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis In Uae. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis In Uae reduced the rate of absorption of the latter without changing the AUC. Can I Buy Cialis Over The Counter Uk enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis In Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis In Uae in patients receiving nitrates is contraindicated

Pharmacokinetics

The pharmacokinetics of Cialis In Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis In Uae in persons without erectile dysfunction.

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After taking Cialis Online Miglior Prezzo inside Cialis In Uae is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Online Kaufen Legal does not depend on the meal, so Cialis In Uae® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis In Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis In Uae 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis In Uae is distributed in the tissues of the body.

The plasma protein binding of Where Can You Buy Cialis Over The Counter at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis In Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis In Uae. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Kaufen Online Rezeptfrei when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Buy Cialis In Tokyo is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Generico Online Recensioni when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Cost In Uae (AUC), patients with severe renal insufficiency are not recommended to use Cialis In Uae®.

The pharmacokinetics of Cialis In Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Buy Cialis In Dublin Buy Cialis In Tokyo® patients with severe liver failure must first assess the risk and benefit of Cialis In Uae.

In patients with diabetes mellitus during the use of Cialis In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Mechanism of action

The active substance of Cialis In Uae is Comprar Cialis Online Entrega 24 Horas, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis Generico Online Italia Consegna Veloce.

Rules of admission

The duration of the generic Cialis In Uae reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis In Uae should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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