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The pharmacokinetics of Cialis Buy Dubai in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

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The plasma protein binding of Cialis Buy Dubai at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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In healthy individuals, the average clearance of Comprar Cialis Online Entrega 24 Horas when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Buy Dubai is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Buy Dubai when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

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The pharmacokinetics of Cialis Kaufen Online Rezeptfrei in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Online Kaufen Deutschland Cialis Buy Dubai® patients with severe liver failure must first assess the risk and benefit of Cialis Buy Dubai.

In patients with diabetes mellitus during the use of Cialis Buy Dubai AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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Inside. Use of Cialis Buy Dubai Buy Cialis Over The Counter In Canada according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Online Kaufen Erfahrungen at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis In Makati. The maximum daily dose of Cialis Buy Dubai is 20 mg. the Use of Cialis Buy Dubai according to the indication of BPH or ED/BPH. The recommended dose of Cialis Buy Dubai when used once a day is 5 mg; Cialis Buy Dubai should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Buy Dubai is contraindicated.

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Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

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Clinical pharmacology

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The efficacy and safety of Buy Cialis Miami (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Buy Cialis Denmark 1 time per day. In studies of the primary efficacy of Cialis Buy Dubai at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Buy Dubai at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Buy Dubai in patients with BPH — inhibition of PDE-5 Cialis Buy Dubai, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Buy Dubai Cialis Buy Dubai according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Buy Dubai at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Buy Dubai. The maximum daily dose of Cialis Buy Dubai is 20 mg.

The use of Cialis Buy Dubai Buy Cialis Denmark for indication of BPH or ED/BPH.The recommended dose of Cialis Buy Dubai when used once a day is 5 mg; Cialis Buy Pakistan should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Buy Dubai once a day is not recommended.

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