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The pharmacokinetics of Cialis Online Kopen Ervaringen in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Online Kopen Ervaringen in persons without erectile dysfunction. Absorption After taking Cialis Online Kopen Ervaringen inside Cialis Online Kopen Ervaringen is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Online Kopen Ervaringen does not depend on the meal, so Cialis Online Kopen Ervaringen can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.


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Mechanism of action

The active substance of Cialis Uae is Comprar Cialis Online Mexico, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis Online Miglior Prezzo.

Rules of admission

The duration of the generic Cialis Uae reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Uae should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

To sum up: buy Cialis Uae (Cialis 20 Mg Price Uae) should be because

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Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Farmacia Online España pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Uae is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Buy Cialis Over The Counter Usa, Cialis Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Online Italia Consegna Veloce.

Side effects and overdose

Due to the well-studied experience of Comprar Cialis Online En Usa, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Clinical pharmacology

Cialis Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Uae leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Online Miglior Prezzo has no effect in the absence of sexual arousal.

In vitro studies have shown that Can I Buy Cialis Over The Counter Australia is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Uae on PDE-5 is more active than on other PDES. Cialis Uae is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Uae is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis Uae is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Uae is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis Uae in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Uae does not cause a significant change in heart rate.

Cialis Uae does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Uae on visual acuity, electroretinogram, intraocular pressure and pupil size.

Pharmacokinetics

The pharmacokinetics of Cialis Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Uae in persons without erectile dysfunction. Absorption After taking Cialis Uae inside Cialis Uae is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Buy Cialis Taiwan does not depend on the meal, so Cialis Uae can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption. The pharmacokinetics of Cialis Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. The distribution of Css in plasma is achieved within 5 days when taking Comprar Cialis Online En Usa 1 time/day. The average Vd is about 63 liters, which indicates that Cialis Uae is distributed in the tissues of the body. The plasma protein binding of Cialis Uae at therapeutic concentrations 94%. In healthy individuals, less than 0.0005% of the administered dose was found in sperm. Metabolism Cialis Uae is mainly metabolized with the participation of CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Uae. Therefore, the concentration of this metabolite is not clinically significant. Excretion In healthy individuals, the average clearance of Cialis Uae when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Online Miglior Prezzo is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose). Pharmacokinetics in special clinical cases, protein Binding does not change with impaired renal function. Healthy elderly patients (65 years and more) had a lower clearance of Cialis Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment. In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Uae (AUC), patients with severe renal insufficiency are not recommended to use Cialis Uae. The pharmacokinetics of Cialis Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Uae to patients with severe liver failure, it is necessary to pre-assess the risk and benefit of using Cialis Buy South Africa. In patients with diabetes mellitus during the use of Cialis Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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