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Cialis Farmacia Online España is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Cialis Farmacia Online España. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Cialis Farmacia Online España reduced the rate of absorption of the latter without changing the AUC. Cialis Farmacia Online España enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Farmacia Online España on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis Farmacia Online España in patients receiving nitrates is contraindicated


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Information

Effect of other drugs on Cialis Farmacia Online España

Cialis Online Snabb Leverans is mainly metabolized with the participation of the CYP3A4 isoenzyme. Selective inhibitor of CYP3A4, ketoconazole (400 mg/day) increases the AUC of Cialis Farmacia Online España in a single dose by 312% and SMACNA 22%, and ketoconazole (200 mg/day) increases the AUC of Cialis 20mg Uae in a single dose by 107% and Smachna 15% relative to the AUC values for Cialis Online Italia Consegna Veloce Smartelco one. Ritonavir (200 mg 2 times a day), an inhibitor of isoenzymes CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of Cialis Farmacia Online España in a single dose by 124% without changing Cmax. Although no specific interactions have been studied, it can be assumed that other HIV protease inhibitors such as saquinavir and CYP3A4 isoenzyme inhibitors such as erythromycin and Itraconazole increase Cialis Price In Uae Dirham activity.

Selective inducer of CYP3A4, rifampin (600 mg/day), reduces the exposure of a single dose of Cialis Farmacia Online España (AUC) by 88% and SMACNA 46% relative to the AUC values for Cialis 20 Mg Price Uae Smartelco one. It can be assumed that the simultaneous use of other inducers of CYP3A4 isoenzyme should also reduce the concentration of Cialis Online Kaufen österreich in plasma.

Simultaneous administration of antacid (magnesium hydroxide/aluminum hydroxide) and Cialis De Vanzare Online reduces the rate of absorption of Cialis Farmacia Online España without changing the area under the pharmacokinetic curve for Where Can I Buy Cialis Over The Counter Usa. The increase in gastric pH as a result of the H2-histamine receptor blocker nizatidine had no effect on the pharmacokinetics of Cialis Farmacia Online España.

The safety and effectiveness of the combination of Cialis Farmacia Online España with other types of treatment of erection disorders have not been studied, so the use of such combinations is not recommended.

Buy Lilly Cialis Uk does not potentiate the increase in bleeding time caused by taking acetylsalicylic acid.

Pharmacokinetics

The pharmacokinetics of Cialis Farmacia Online España in patients with erectile dysfunction is similar to the pharmacokinetics of Buy Liquid Cialis in persons without erectile dysfunction.

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After taking Cialis Farmacia Online España inside Cialis Price In Uae is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Farmacia Online España does not depend on the meal, so Cialis Kuala Lumpur Online® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Farmacia Online España in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

Distribution

Css in plasma are attained within 5 days while taking Cialis Farmacia Online España 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Farmacia Online España is distributed in the tissues of the body.

The plasma protein binding of Cialis Farmacia Online España at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

Metabolism

Cialis Farmacia Online España is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Farmacia Online España. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Farmacia Online España when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Cialis Buy South Africa is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis Online Kaufen Ohne Rezept when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Farmacia Online España (AUC), patients with severe renal insufficiency are not recommended to use Cialis Farmacia Online España®.

The pharmacokinetics of Cialis Farmacia Online España in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Cialis Farmacia Online España Cialis Online Italia Consegna Veloce® patients with severe liver failure must first assess the risk and benefit of Cialis Online San Marino.

In patients with diabetes mellitus during the use of Cialis Farmacia Online España AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Online Miglior Prezzo pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Farmacia Online España is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Farmacia Online España, Cialis Farmacia Online España is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Farmacia Online España.

Side effects and overdose

Due to the well-studied experience of Cialis Farmacia Online España, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
  • Dizziness and vomiting
  • A rush of blood to the face
  • Nasal congestion

When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Clinical pharmacology

Cialis Farmacia Online España is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Farmacia Online España leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Farmacia Online España has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Farmacia Online España is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Farmacia Online España on PDE-5 is more active than on other PDES. Cialis Farmacia Online España is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis 5 Mg Online Italia is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis Farmacia Online España is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Cialis Farmacia Online España is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis Farmacia Online España improves erection and increases the possibility of a full sexual intercourse.

Cialis Farmacia Online España in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Farmacia Online España does not cause a significant change in heart rate.

Cialis Farmacia Online España does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis Farmacia Online España on visual acuity, electroretinogram, intraocular pressure and pupil size.

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