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The active substance of Cialis In Uae Price is Cialis In Uae Price, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

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Be sure to consult your doctor before taking Cialis In Uae Price pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

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Side effects and overdose

Due to the well-studied experience of Cialis Online Miglior Prezzo, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

  • Mild headaches
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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Pharmacological action

Cialis In Uae Price for the treatment of erectile dysfunction. Cialis In Uae Price is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis In Uae Price leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Online Kaufen österreich has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis In Uae Price is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis 5mg Price In Uae on PDE5 is more active than on other PDES. Cialis In Uae Price is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis In Uae Price is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis In Uae Price is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis In Uae Price is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

Cialis In Uae Price improves erection and increases the possibility of a full sexual intercourse.

Cialis In Uae Price in healthy individuals does not cause a significant change in systolic and diastolic pressure in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. respectively) and in the standing position (the average maximum decrease is 0.2/4.6 mm Hg. art., respectively). Cialis In Uae Price does not cause a significant change in heart rate. Cialis In Uae Price does not cause changes in color recognition (blue/green), due to its low affinity for PDE6. In addition, there is no effect of Cialis In Uae Price on visual acuity, electroretinogram, intraocular pressure and pupil size.

Several studies have been conducted to assess the effect of daily Cialis In Uae Price on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis In Uae Price compared to placebo.

The efficacy and safety of Cialis In Uae Price (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis In Uae Price 1 time/day. In studies of the primary efficacy of Cialis Online Farmacia Italiana at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Cialis In Uae Price at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

Dosage and administration

Inside. Use of Cialis Legal Online Bestellen Buy Cialis Johannesburg according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis In Uae Price at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis In Uae Price. The maximum daily dose of Cialis In Uae Price is 20 mg. the Use of Cialis In Uae Price according to the indication of BPH or ED/BPH. The recommended dose of Cialis In Uae Price when used once a day is 5 mg; Cialis Generico Online Italia Consegna Veloce should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis In Uae Price is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

Overdose

Symptoms: with a single appointment to healthy individuals Cialis Uae Price at a dose of up to 500 mg and patients with erectile dysfunction - repeatedly up to 100 mg/day, the undesirable effects were the same as when using Cialis In Uae Price in lower doses. Treatment: in case of overdose, standard symptomatic treatment is necessary. In hemodialysis Cialis In Uae Price practically displayed.

Interaction with other drugs

Cialis Online Kaufen Schweiz is mainly metabolized by the enzyme CYP3A4. Selective inhibitor CYP3A4 ketoconazole increases AUC by 107%, and rifampicin reduces it by 88%. Although specific interactions have not been studied, it can be assumed that protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and Itraconazole, increase the activity of Can You Buy Cialis Over The Counter Uk. The simultaneous administration of antacid (magnesium hydroxide/aluminium hydroxide) and Can You Buy Cialis Over The Counter Yet reduced the rate of absorption of the latter without changing the AUC. Cialis In Uae Price enhances the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis In Uae Price on the metabolism of nitric oxide and cGMP. Therefore, the use of Cialis In Uae Price in patients receiving nitrates is contraindicated

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