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Clinical pharmacology

Cialis Buy South Africa is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Buy South Africa leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Buy South Africa has no effect in the absence of sexual arousal.

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Inside. Use of Cialis Buy South Africa Cialis Generico Online Recensioni according to the indication of erectile dysfunction (ED). For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose can be reduced to 2.5 mg, depending on individual sensitivity. For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Online Kaufen Forum at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Buy South Africa. The maximum daily dose of Cialis Buy South Africa is 20 mg. the Use of Cialis Buy South Africa according to the indication of BPH or ED/BPH. The recommended dose of Cialis Buy South Africa when used once a day is 5 mg; Cialis Buy South Africa should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with mild renal insufficiency (creatinine Cl from 51 to 80 ml/min) and moderate (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required. In patients with severe renal failure (Creatinine CL <30 ml/min and hemodialysis): use of Cialis Buy South Africa is contraindicated.

Side effect

Most often: headache, dyspepsia. Possible: back pain, myalgia, nasal congestion, blood flow to the face. Rarely: swelling of the eyelids, pain in the eyes, conjunctival hyperemia, dizziness.

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Clinical pharmacology

Several studies have been conducted to assess the effect of daily Buy Cialis Super Active on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Buy Cialis Over The Counter Canada compared to placebo.

The efficacy and safety of Cialis Buy South Africa (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Buy South Africa 1 time per day. In studies of the primary efficacy of Can You Buy Cialis Over The Counter at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Buy South Africa at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Buy South Africa in patients with BPH — inhibition of PDE-5 Cialis Uae, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Generico Online Italia Cialis Buy South Africa according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

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The use of Cialis Buy South Africa Cialis Buy South Africa for indication of BPH or ED/BPH.The recommended dose of Cialis Buy South Africa when used once a day is 5 mg; Cialis Buy South Africa should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis Buy South Africa once a day is not recommended.

Pharmacological action

Cialis Buy South Africa for the treatment of erectile dysfunction. Cialis 20mg Price In Uae is a reversible selective inhibitor of cyclic guanosine monophosphate (cGMP) PDE5. When sexual arousal causes local release of nitric oxide, inhibition of PDE5 by Cialis Buy South Africa leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Cialis Buy South Africa has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis Online Italia Consegna Veloce is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis Buy South Africa on PDE5 is more active than on other PDES. Cialis Online Kaufen Ohne Rezept Erfahrungen is 10,000 times more potent against PDE5 than against PDE1, PDE2, PDE4 and PDE7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis Online Italia Consegna Veloce is 10,000 times more active in blocking PDE5 than PDE3, an enzyme that is found in the heart and blood vessels. This selectivity concerning PDE5 compared to ФДЭ3 is important because ФДЭ3 is an enzyme participating in the reduction of cardiac muscle. In addition, Cialis Buy South Africa is approximately 700 times more active against PDE5 than against PDE6 found in the retina and responsible for photo transmission. Cialis Tablets In Uae is also showing the action in 9000 times more potent against PDE5 compared to its effect on PDE8, PDE9 and PDE10, and 14 times more potent against PDE5 compared to PDE11. Tissue distribution and physiological effects of inhibition of PDE8 - PDE11 have not yet been clarified.

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